PULSED SOLID-STATE LASER SOURCE FOR PHOTODYNAMIC THERAPY

描述(摘自申请者摘要)：光动力疗法(PDT) 利用血卟啉衍生物(HPD)和连续的氩气泵浦染料激光器 调谐到630 nm已经被证明是一种有希望的治疗方法 各种形式的癌症。然而，由于组织渗透率最大化， 波长大于700 nm，已经做出了很大的努力 寻找在近红外(670-900 nm)吸收的新染料。这个 最近开发的钛宝石激光器的调谐范围与此重叠 因此，为染料激光器提供了一种全固态替代方案。 第一阶段的工作将涉及细胞水平的实验，使用两种新的 光敏剂：磺化氯铝酞菁(CASPc) 苯并吗啉衍生物单酸A(BPD)，在680 nm和690 nm处吸收 分别为NM。尽管钛蓝宝石系统也可以运行 脉冲或连续波在这个波长范围内，初步实验将 用脉冲激光进行，因为连续钛蓝宝石将产生 结果与CW染料非常相似。尽管主要原因是 在连续波照射下细胞死亡的原因是单线态氧的产生， 脉冲激光产生的高强度能级可能会感光 通过非氧依赖机制。长期目标将是发展 一种临床合格的用于光动力疗法的固体激光器。

DESCRIPTION (Adapted from applicant's abstract):Photodynamic therapy (PDT) utilizing hematoporphyrin derivative (HPD) and a cw argon-pumped dye laser tuned to 630 nm has been shown to be a promising treatment for a number of forms of cancer. However, because tissue penetration is maximized for wavelengths greater than 700 nm, substantial effort has been directed towards finding new dyes which absorb in the near-ir (670-900 nm). The tuning range of the recently developed Ti:sapphire laser overlaps this regions, thus providing an all-solid-state alternative to the dye laser. The Phase I effort will involve cell-level experiments using two new photosensitizers: sulfonated chloraluminum phthalocyanine (CASPc) and benzoporphryin derivative monoacid A (BPD) which absorb at 680 nm and 690 nm respectively. Although a Ti:sapphire system can be operated either pulsed or cw in this wavelength region, the initial experiments will be performed with a pulsed laser, since the cw Ti:sapphire would produce results that were very similar to the cw dye. Although the primary cause of cell necrosis under cw irradiation is the creation of singlet oxygen, the high intensity levels generated by the pulsed laser may photosensitize by non-oxygen-dependent mechanisms. The long term goal would be to develop a clinically qualified solid-state laser for PDT.