MATHEMATICAL MODEL FOR RENAL TRANSPLANT EVALUATION

描述(改编自申请人的摘要)：虽然肾脏 事实证明，与移植相比，移植既有用又划算。 对于透析来说，并发症很常见。肾移植的成功很大一部分 移植取决于是否能及时找出原因。 功能受损，以便在治疗之前进行适当的治疗 这种情况变得不可逆转。尽管核医学系统和 有几种分析方法可用于评估肾功能， 目前还不存在将所有信息结合在一起的评估系统 时间-活动曲线的分段，以提供对 肾功能。一种改进的放射性核素肾图分析方法将 有助于早期诊断，提高诊断的准确性，以及 减少对活组织检查的需求；自动化程序将节省技术人员 时间，从而使详细分析变得可行；将结果呈现为 每个类别的诊断概率将非常有助于 临床医生并会明确诊断的保证程度； 从这种表述来看，做活组织检查的合理标准应该是 进化。该项目中的调查人员建议开发和评估 一个全面的数学、生理模型，将包括所有 进行肾脏整体分析时时间-活动曲线的阶段性 功能。系数将被导出，表示速率和 与示踪剂通过 肾脏的不同部分。这些系数将相互关联 与个别病例的诊断相一致。软件将在 这样一种方式，它应该适用于通常的核医学 连接到计算机或连接到它们的工作站。因此，如果成功， 该产品应广泛适用于任何有肾脏的设施 需要分析处理放射性核素的移植计划 移植评估。

DESCRIPTION (Adapted from the Applicant's Abstract): Although renal transplantation has proved to be both useful and cost-effective compared to dialysis, complications are frequent. Much of the success of renal transplantation is dependent upon prompt identification of the cause of impairment of function so that appropriate treatment can be applied before the condition becomes irreversible. Although nuclear medicine systems and several methods of analysis are available to evaluate kidney function, currently no evaluation system exists which combines information from all segments of the time-activity curve to provide a global assessment of renal function. An improved means of radionuclide renogram analysis would contribute to earlier diagnosis, improved accuracy of diagnosis, and reduced need for biopsies; an automated program would save technologists time and, thereby, make detail analysis practicable; presenting results as probability of diagnosis in each category would be very helpful to clinicians and would make the degree of assurance of the diagnosis clear; from this sort of presentation rational criteria for doing biopsies should evolve. The investigators in this project propose to develop and evaluate a comprehensive mathematical, physiologic model which will include all phases of the time-activity curve in performing a global analysis of renal function. Coefficients will be derived representing rate and concentration data corresponding to the transit of the tracer through the various compartments of the kidney. These coefficients will be correlated with the diagnoses of individual cases. Software will be developed in such a way that it should be applicable to the usual nuclear medicine computers or to the work stations linked to them. Thus, if successful, the product should be widely applicable to any facility with a renal transplant program desiring analytical treatment of radionuclide transplant evaluations.