INTEGRATED COLUMN/MULTISENSOR MICROBORE SYSTEM

弗里特型库仑传感器的基本特性使它们 独特适用于高灵敏度液相色谱电化学 在专门设计的微孔系统中进行检测， 特性.建议的工作是基于优化一个概念上简单的 其中多传感器阵列中的第一传感器是 保留微孔柱的熔块。初步研究表明 开发作为集成系统的概念的期望-泵， 色谱柱、传感器、检测器-最大限度地减少频带扩展和噪声。具体 主要设计目标是对儿茶酚胺的10 fg灵敏度， 根据可行性和要求确定了代谢产物 提出的微透析的具体应用研究， 微组织分析。优化分辨率的次要设计目标， 还提出了利用多个串联传感器AR-E。该提案 本发明的目的在于开发一种模块化系列装置， 研究市场作为完整的独立软件包或改造， 现有的泵和检测器。

The basic characteristics of fritt type coulometric sensors make them uniquely suited for high sensitivity liquid chromatography electrochemical detection in microbore systems specifically engineered to optimize their properties. The proposed work is based on optimizing a conceptually simple design in which the first sensor in a multiple sensor array is the retaining fritt of a microbore column. Preliminary studies have indicated the desirability of developing the concept as an integrated system - pump, column, sensor, detector - to minimize bandspreading and noise. Specific primary design goals of 10 fg sensitivity for catecholamines and metabolites have been established based on feasibility and the requirements of the specific applications studies proposed in microdialysis and microtissue assays. secondary design goals of optimizing resolution by utilizing multiple series sensors ar-e also proposed. The proposal is directed towards the development of a modular series of devices for the research market as either complete stand alone packages or retrofits to existing pumps and detectors.