TEA-CO2 DEBRIDEMENT OF BURN ESCHAR (7130-260)

描述：(主要调查人员摘要)这项研究的目标 应用是研究商业化利用的可行性 可用的重复脉冲CO_2激光技术用于精密、 烧伤全层治疗中控制清创术的应用 皮肤灼伤。初步调查显示，这一狭窄区域 二氧化碳TEA激光留下的热凝组织可以提供几乎 最佳植皮条件。 第一阶段的研究将包括动物实验以评估有效性。 TEA激光清除受控全层真皮焦痂的研究 伯恩斯。还将对消融率进行定量测量。 作为在底层组织中发现的残余热损伤的程度。 还将研究使用快速、实时光热技术的效用 放射测量作为确定何时坏死/存活的反馈指导 已到达组织界面。 如果成功，这项研究将导致开发一种 显著改进技术，以实现快速、精确和可控的 烧伤焦痂清创术，出血量少，创面损伤小 活组织。我们的目标是提高真皮手术的成功率 可以移植表皮组织，从而降低发病率和 死亡率和改善美容外观。

DESCRIPTION: (Principal Investigator's Abstract) The objective of this application is to investigate the feasibility of utilizing commercially available repetitively-pulsed CO 2 TEA laser technology for the precise, controlled debridement of burn eschar in the treatment of full thickness dermal burns. Preliminary investigations suggest that the narrow zone of thermally-coagulated tissue left by the CO 2 TEA laser could provide nearly optimum conditions for skin grafting. Phase I studies will involve animal experiments to assess the effectiveness of the TEA laser for debriding eschar from controlled full thickness dermal burns. Quantitative measurements will be made of the ablation rate as well as the extent of residual thermal damage found in the underlying tissue. Also investigated will be the utility of using fast, real-time photothermal radiometry as feedback guidance for determining when the necrotic/viable tissue interface has been reached. If successful this research would lead to the development of a significantly improved technique for the rapid, precise, and controlled debridement of burn eschar with minimal blood loss and damage to underlying viable tissue. The objective is to increase the success with which dermal and epidermal tissue can be grafted thereby lowering morbidity and mortality and improving cosmetic appearance.