SOLID STATE LASER FOR VASCULAR LESION TREATMENT

描述(摘自申请者摘要)：波特温葡萄酒的治疗 皮肤的斑点、毛细血管扩张和其他微血管畸形 通过激光手术得到了极大的改善。在1981-83年间，工作人员 安德森和他的同事们发现了一种名为“选择性”的方法 光热分解“，这导致了有效的但基本上不会留下疤痕 治疗。这种方法后来得到了改进，现在是一种成熟的、 在皮肤科被广泛接受，本质上是独一无二的治疗方法。 目前，激光系统最好地满足了 治疗方法是长脉冲染料激光器，工作波长为585 nm， 可见光谱的黄色区域。有很多问题 涉及到染料激光器的工作特性和用途。在 第一阶段提案，调查员计划调查 一种固体激光系统，它将取代现有的激光并消除 染料激光的一些问题，如果不是全部的问题。一种改进的黄色信号源 可以使血管病变治疗更广泛地获得，并降低 成本。

DESCRIPTION (Adapted from applicant's abstract):The treatment of portwine stains, telangiectases and other microvascular malformations of the skin has been greatly improved by laser surgery. Between 1981-83, work by Anderson and colleagues identified an approach called "selective photothermolysis", which led to effective yet essentially non-scarring treatments. This approach has since been refined and is now a mature, well-accepted, and essentially unique treatment in dermatology. At present, the laser system best satisfying the requirements of the treatment is a long-pulse dye laser, operating at a wavelength of 585 nm, the yellow region of the visible spectrum. There are a number of problems related to the operating characteristics and use of the dye laser. In the Phase I proposal, the investigator's plan to investigate the development of a solid state laser system that would replace current lasers and eliminate some, if not all of the dye-laser problems. An improved yellow source could make vascular-lesion treatment more widely available and lower in cost.