BIOLOGICAL PROPERTIES OF GOSSYPOL AND DERIVATIVES

将合成二倍半萜棉酚的衍生物。 这主要涉及醛官能团的修饰 棉酚团。棉酚及其衍生物将在#年进行评估 三种不同的生物检测系统。 1.将对棉酚及其衍生物进行评估 对恶性疟原虫的抗寄生活性。 活性将与药物抑制的能力进行比较 寄生虫乳酸脱氢酶，推测的目标。 2.将评估棉酚及其衍生物的抗病毒作用 针对II型单纯疱疹的特性。 3.对棉酚及其衍生物的性能进行评估 作为从人胎盘中提取的醛糖还原酶抑制剂。这种酶 是药物治疗的靶点，这些药物可能对治疗 糖尿病并发症。

Derivatives of the disesquiterpene gossypol will be synthesized. This primarily involves modification of the aldehyde functional groups of gossypol. Gossypol and derivatives will be evaluated in three different biological assay systems. 1. Gossypol and derivatives will be evaluated for their antiparasitic activity against the malarial parasite P.falciparum. Activity will be compared with the ability of the drugs to inhibit parasite lactate dehydrogenase, the putative target. 2. Gossypol and derivatives will be evaluated for their antiviral properties against herpes simplex type II. 3. Gossypol and derivatives will be evaluated for their properties as inhibitors of aldose reductase from human placenta. This enzyme is the target for drugs which may be useful in the treatment of diabetic complications.