REPLACEMENT MASS SPECTROMETER

伊利诺伊大学芝加哥分校(UIC)健康科学中心， 是一个主要的医疗中心，在美国拥有庞大的生产部门 与医学和健康相关的科学。至少35项研究 该中心的项目主要由NIH基金支持，依赖于 质谱仪(MS)用于他们的研究，其中几个是严重的 依赖于这样的MS仪器。目前，有两个质谱仪 为这些研究项目服务。除了一个全职的，还有另一个 兼职操作员，这两台光谱仪也支持大约30 来自各种研究项目的动手用户。这些仪器是 全天候计划(365天/年)，然而， 请求的仪器时间的一半必须被拒绝，因为超过 订阅。此外，还有第三件有20年历史的乐器，它 是有机药物化学和生药学的支柱 最近，由于缺乏零部件，研究项目不得不被取消。 重要的是，目前的手段没有规定引入 以及极性、高相对分子质量物质的质量分析。生物医学 UIC的研究将极大地促进其进行大规模研究的能力 多种多肽、DNA加合物、天然产物和 属于这一类别的合成衍生品。因此，现在 无论是在数量上还是在质量上，仪器都是不够的。 为了解决这些困难，我们建议获得一个中等质量 配备了快速原子轰击、热喷雾LC的光谱仪 接口、GC接口和更高的质量范围功能。现在 然后，MS工作负载(和超载)将集成在现有的两个 分光计和新仪器以这样的方式采取 各具特色的设计优势。 与另一名博士级别的光谱学家相结合，由 大学，这种仪器将为UIC提供必要的设备 提供所需的极性、较高分子量的质量分析 物质，以及提供足够的工具时间，以涵盖 目前超载。

The Health Sciences Center of the University of Illinois at Chicago (UIC), is a major medical center with large and productive departments in the medical and health-related sciences. At least thirty-five research programs at this Center, largely supported by NIH funds, are dependent on mass spectrometry (MS) for their research, and several are heavily dependent on such MS instrumentation. At present, two mass spectrometers service these research programs. In addition to one full-time, and another part-time operator, the two spectrometers also support approximately thirty hands-on users from the various research programs. The instruments are scheduled on an around-the-clock- basis (365 days/year) and yet, as much as half of the requested instrument time must be refused because of over subscription. In addition, a third, twenty-year old instrument, which served as the backbone of the organic medicinal chemistry and pharmacognosy research programs, recently had to be scrapped for lack of parts. Importantly, the present instrumentation does not provide for introduction and mass analysis of polar, high molecular weight substances. Biomedical research at UIC would be greatly facilitated by the ability to do mass analysis on a variety of peptides, DNA-adducts, natural products and synthetic derivatives falling in this category. Thus, present instrumentation is inadequate both quantitatively and qualitatively. To address these difficulties, we propose to acquire a medium level mass spectrometer equipped with, fast atom bombardment, thermospray-LC interface, GC interface, and higher mass range capabilities. The present MS work load (and overload) will then be integrated over the two existing spectrometers and the new instrumentation in such a fashion as to take advantage of the design characteristics of each. In combination with an additional Ph.D. level spectroscopist, provided by the University, such instrumentation will give UIC the equipment necessary to provide the needed mass analyses of polar, higher molecular weight substances, as well as provide sufficient instrument time to cover the present overload.