X-RAY FLOURESCENCE SPECTROMETER SYSTEM

研究项目通常在以下情况下取得重大进展 适当的新的分析和实验程序 发展起来的。我们已经开发出了X射线荧光技术 用于测量生物组织中的元素，这将提供 先进的分析能力，这是以前没有的 有可能。为了充分利用这一成就，我们正在 申请购买X光荧光仪的资金 (XRF)光谱仪系统。在XRF的基本操作中 光谱学系统，对样品的光子轰击 产生每个通过的元素所特有的X射线 通过样品的铍窗口，敲击探测器并 由多道分析器进行分析。这台仪器检测到 摩尔重量大于19的所有元素。 首席调查员开发了一种新技术，利用 KEVEX 0700型X射线荧光光谱仪检测定量 浓度大于10微克分子的几种元素 单独或同时，在各种生物组织中。使用 这些样品制备方面的技术进步，XRF 光谱学将简化许多分析程序，这些程序包括 就时间和资源而言，现在相当繁琐和昂贵。 我们研究实验室对XRF系统的主要需求 就是获得100%使用设备的权利。这台仪器将会是 用于美国国立卫生研究院相关项目开发的新对比 用于MRI、CT和B超的增强剂以及 发展新的无创性MRI诊断和生理学 技巧。当前访问SAN中的一个XRF系统 迭戈地区(北岛海军基地)有限，不方便， 效率极低，严重限制了我们的进步 国立卫生研究院的研究项目。当可以访问时，XRF系统仍然是 仅在全程所需时间的一小部分内可用 为我们的NIH项目提供这项技术的优势。 由于仪器的多功能性和技术的进步 我们正在进行样品制备，这套XRF系统将 多年来一直有用。它仍将是一个理想的核心乐器， 适合今天由美国国立卫生研究院赞助的重要项目 足够灵活，与未来的项目相关-无价的 实现今天和明天研究目标的工具。

Research programs often make significant advancements when appropriate new analytical and experimental procedures are developed. We have developed and X-ray fluorescence technique for measuring elements in biological tissues that will provide advanced analytical capability which previously has not been possible. To take full advantage of this achievement, we are requesting funds for the purchase of an X-Ray Fluorescence (XRF) Spectrometer system. In the basic operation of an XRF spectroscopy system, a photon bombardment of the sample produces X-rays characteristic for each element which pass through a beryllium window of the sample, strike a detector and are analyzed by a multichannel analyzer. This instrument detects all elements with mol wt greater than 19. The principle investigator developed new techniques utilizing a KEVEX 0700 XRF spectrometer for detecting and quantitating several elements in concentrations greater than 10 umolar, either separately or simultaneously, in various biological tissues. With these technical advances in sample preparation, XRF spectroscopy will simplify many analytical procedures which are now quite tedious and expensive in terms of time and resources. The primary need for the XRF system in our research laboratories is to gain 100% access to the equipment. This instrument will be used in NIH projects related to the development of new contrast enhancement agents for MRI, CT and ultrasonography and for developing new non-invasive MRI diagnostic and physiologic techniques. Current access to the one XRF system in the San Diego region (North Island Naval Base) is limited, inconvenient, terribly inefficient and severely restrictive to the progress of our NIH research programs. When accessible, the XRF system is still only available for a small fraction of the time needed to take full advantage of this technology for our NIH programs. Because of the instrument's versatility and the technical advances we are making in sample preparation, this XRF system will be useful for many years. It will remain an ideal core instrument, suitable for today's important NIH-sponsored projects while flexible enough to be relevant for future projects --- an invaluable tool for reaching today's and tomorrow's research goals.