Discipline Hopping x2: a next generation framework for multidisciplinary research between mathematics and regenerative medicine

我们的互惠学科跳跃提案的总体目标是探索和确定数学建模可以嵌入再生医学管道的所有阶段的方法，从最初的实验室实验到细胞微环境的定量评估，再到组织工程方案的优化，通过成功地转化为临床。再生医学领域已经达到了发展的关键点。作为过去15-20年来令人兴奋的新进展，英国和全球医疗保健治疗的重大变革潜力得到了认可。然而，这项任务的复杂性被低估了。为了实现再生医学提供的全部临床潜力，该领域的许多方面必须根据科学，监管和临床社区的标准和严格性进行确定和定义。虽然已经发现了许多令人兴奋的新技术和基于细胞的方法，但它们缺乏定量方法和预测能力，而这是走向临床的漫长旅程所必需的。要真正将数学嵌入再生医学，需要对两个领域之间的相互作用有更深入的了解，这可以通过双方科学家的合作来实现。为了让我们在定量再生医学中定义一个新的领域，我们需要跨学科的参与和接触。我们将通过在彼此的研究机构花费专门的时间来实现这一目标。我们的研究成果将包括一篇观点文章，在国际领先的高质量期刊上发表研究论文，与国家和国际会议相关的研讨会，以及一个新的跨学科博士培训中心的框架应用程序，这将在数学和再生医学之间的界面上培养新一代的高技能研究人员。

The overall goal of our reciprocal Discipline Hopping proposal is to explore and identify ways in which mathematical modelling may be embedded in all stages of the regenerative medicine pipeline, from the initial laboratory experiments, to quantitative assessment of the cellular microenvironment, to optimisation of tissue engineering protocols, through to successful translation to the clinic.The field of regenerative medicine has reached a key point in its development. As an exciting new advance brought in over the past 15-20 years, the potential for a major step change in healthcare therapy in the UK and worldwide was recognised. However, the complexity of the task was underestimated. To realise the full clinical potential offered by regenerative medicine, many facets of the field must be determined and defined to the standards and rigour of the scientific, regulatory and clinical community. While there is no doubt that many exciting and novel technologies and cell based approaches have been identified, they lack the quantitative approach and the predictive ability which is needed to make the long journey to the clinic.To truly embed mathematics in regenerative medicine, a deeper understanding of the interplay between the two fields is required, achievable through a collaborative approach for both scientists. In order for us to define a new field in Quantitative Regenerative Medicine, we need participation in, and exposure from, both disciplines across the divide. We will achieve this by spending dedicated time in each other's research Institutions. Outcomes from our research will include an opinion article, research publications in internationally-leading high-quality journals, workshops linked to national and international meetings, and a framework for a novel interdisciplinary Centre for Doctoral Training application, which will train a new generative of highly skilled researchers at the interface between mathematics and regenerative medicine.