Dynamics in DOPC: muon hyperfine coupling constants for an 18:1 delta-9 cis chain

惰性麻醉气体如Xe和N2O的作用仍不清楚，特别是这些气体与小分子麻醉中涉及的受体只有微弱的相互作用。一种可能性是通过改变受体嵌入其中的膜的动力学来间接影响。最近在Ral-ISIS Muon设备上的实验表明，Muon可以作为外部探针来研究作为模型膜的磷脂双层的动力学。然而，需要在连续的Muon源PSI上进行进一步的Muon实验，以完成对早期数据的分析，并能够全面解释Muon谱中看到的变化。PSI的实验将产生Muon超精细耦合常数，从而能够完全指认磷脂双层暴露在Xe或N2O中时的ALC-MuSR谱。

The action of inert anaesthetic gases such as Xe and N2O is still unclear, particularly as these will have only weak interactions with receptors implicated in small molecule anaesthesia. One possibility is an indirect effect through changing the dynamics of the membrane in which the receptors are embedded. Recent experiments at the RAL-ISIS muon facility have demonstrated that the muon can be used as an external probe for the dynamics of phospholipid bilayers used as a model membrane. Further muon experiments are however required at PSI, a continuous muon source, in order to complete the analysis of the earlier data and allow a full interpretation of the changes seen in the muon spectra. The experiments at PSI will yield the muon hyperfine coupling constant enabling complete assignment of the ALC-MuSR spectra seen when the phospholipid bilayer is exposed to Xe or N2O.