Rapid Fluorescence-based Detection of Bacteria using Quantum Optics

英国国家医疗服务体系每年收治的14.7万例败血症病例中，大多数是由细菌感染引起的。迫切需要快速的工具来检测和鉴定患者样本中的细菌。在英国国家医疗服务体系支付的8.3亿英镑败血症治疗费用和美国医院支付的200亿美元费用中，通过缩短诊断时间可以节省25%的费用。在这个项目中，我们的目标是提供一种新颖的量子光学启发（QPS）设备，该设备可以在5分钟或更短的时间内检测患者样品中标记有新型荧光碳纳米材料的细菌。该系统旨在检测感染的实际原因（细菌），而不是其他点护理设备针对的生物标志物。我们的方法将使抗生素的适当处方，从而限制滥用广谱药物。该项目将使FluoretiQ和布里斯托尔大学处于有利地位，以吸引必要的后续支持，将联合技术诊断解决方案商业化。它还为FluoretiQ提供了利用其QPS系统为新应用程序提供服务的机会，否则现有资源无法实现这一目标。关键词：细菌快速检测，脓毒症，细菌传感器

The majority of the 147,000 sepsis cases seen by the NHS annually, are caused by bacterial infections. There is a pressing need for rapid tools for detecting and identifying bacteria in patient samples. Of the £830 M in sepsis treatment costs paid by the NHS and the USD $20 billion by American hospitals, 25% can be saved by reducing time to diagnosis. In this project, we aim to deliver a novel quantum optics inspired (QPS) device which detects bacteria labelled with new fluorescent carbon nanomaterials in patient samples within 5 mins or less. This system aims to detect the actual cause (bacteria) of the infection as opposed to bio-markers targeted by other Point of Care devices. Our approach will enable the appropriate prescription of anti-biotics and therefore limit the abuse of broad spectrum agents. This project will place FluoretiQ and University of Bristol in a strong position to attract the follow-on support necessary to commercialise the combined technology diagnostic solution. It also provides FluoretiQ the opportunity to leverage its QPS system to service a new application which would otherwise not be possible with current resources. Keywords: Rapid Detection of Bacteria, Sepsis, Bacteria Sensor