HEPATITIS B VIRUS DNA AS COCARCINOGEN IN KAPOSI SARCOMA

Kaposi肉瘤和获得性免疫缺陷的流行现状 综合征（艾滋病/KS）令人震惊。 流行病的发病率不断上升 以及通过性接触、药物外观和血液传播的途径 产品支持病毒病原学。 它进一步表明， 所涉及的基因具有致癌潜力， 卡波西肉瘤 我们在这里要探讨的假设是基于 在分析卡波西肉瘤的肿瘤活检中所做的观察。 我们 发现HBV相关DNA形式在Kaposi中以游离状态存在 肿瘤 因此，拟议的研究将涉及详细和 分子和生物化学特征的彻底调查， 特别是乙型肝炎相关DNA形式在卡波西中的作用， 肉瘤。 进一步探讨卡波西肉瘤的遗传基础 基因，并试图确定细胞癌基因的激活， 无论涉及何种机制，都会诱发肿瘤。

The current epidemics of Kaposi sarcoma and acquired immune deficiency syndrome (AIDS/KS) is alarming. The increasing incidence of the epidemic and its route of transmission by sexual contact, drug appearance, and blood products support the viral etiology. It further suggests that the virus involved is endowed with oncogenic potential which expresses to produce Kaposi sarcoma. The hypothesis we would explore here is based on the preliminary observations made in the analysis of tumour biopsies of Kaposi sarcoma. We found that HBV-related DNA forms existed in an episomal state in Kaposi tumours. The proposed research therefore would involve detailed and thorough investigation of molecular and biochemical characterizations and particularly the role of the hepatitis B-related DNA forms in Kaposi, sarcoma. Furthermore, we would explore the genetic basis of Kaposi sarcoma genesis, and attempt to identify cellular oncogenes whose activation by whatever mechanism involved, induces the tumour.