High-sensitivity multinuclear 600 MHz NMR for synthesis, catalysis and functional materials

新材料和分子的设计、合成和开发是能源储存、农业、健康和医药以及环境可持续塑料领域众多科学进步的核心。在所有这些情况下，一个基本要求是能够理解和准确定义这些分子的结构--这是实现这种核磁共振(核磁共振)谱的最重要的分析技术之一。尽管核磁共振能够提供对分子结构的精细洞察，但它的检测灵敏度相当低，这意味着需要相对大量的非常珍贵的样本来进行分析，尽管这样的数量并不总是可用的。同样的情况是，由于核磁共振提供的信息含量非常高，它提供的数据可能很复杂，难以解释。技术进步可以帮助这两个领域，因此有助于分子设计的进步。通过用液氦将这些前置放大器及其相关的前置放大器冷却到非常低的温度(分别为~25和85开尔文)，可以显著提高检测探针的灵敏度，就像在低温探针或“低温探针”中一样。这使得化学家和材料科学家能够以小得多的数量工作，并更快、更有效地收集有价值的数据。使用更强的磁场还可以提高灵敏度，并导致检测到的信号有更大的信号色散，从而可以研究更复杂和结构多样化的分子。配备高灵敏度低温探头的尖端核磁共振光谱仪将支持化学、材料科学和物理领域的多个世界领先的研究小组，这些研究小组依赖于对分子结构的了解，使这些研究人员保持国际竞争力。它将取代已有15年历史的现有核磁共振仪器，并将为使用这项技术的科学家提供更大的能力、更好的性能、更高的效率和更好的可靠性。这反过来将使与更好的医疗保健相关的新疗法和药物(包括抗生素)、用于食品生产率的先进农用化学品、用于储能的电池技术、可持续聚合物和塑料以及用于未来制造的更高效方法的发现成为可能。

The design, synthesis and development of new materials and molecules sits at the core of numerous scientific advances in energy storage, agriculture, health and medicine, and environmentally sustainable plastics. In all these cases a fundamental requirement is to be able to understand and accurately define the structure of these molecules- one of the most important analytical techniques to achieve this Nuclear Magnetic Resonance (NMR) Spectroscopy. Despite its ability to provide exquisite insights into molecular structures, NMR is hampered by its rather poor detection sensitivity, meaning relatively large quantities of very precious samples are required for analysis, although such quantities are not always available. It is also the case that due to the very high information content provided by NMR, the data it provides can be complex and challenging to interpret. Technological advances can assist in both these areas and so aid in the advancement of molecular design. The sensitivity of the detection probes can be improved significantly by cooling these and their associated preamplifiers to very low temperatures (~25 and 85 Kelvin respectively) with liquid helium, as in cryogenic probes or "cryoprobes". These enable chemists and materials scientists to work with far smaller quantities and collect valuable data more rapidly and efficiently. The use of more powerful magnetic fields also improves sensitivity and leads to greater signal dispersion of the detected signals, allowing the study of more complex and structurally diverse molecules. The cutting-edge NMR spectrometer equipped with a high-sensitivity cryoprobe will support multiple world-leading research groups across chemistry, materials science, and physics that rely on an understanding of molecular structures, enabling these researchers to remain internationally competitive. It will replace an existing NMR instrument that is fifteen years old and will provide scientists employing this technique with greater capabilities, better performance, increased efficiency and improved reliability. This in turn will enable discoveries relevant to new therapeutics and pharmaceuticals (including antibiotics) for better healthcare, advanced agrochemicals for food productivity, battery technologies for energy storage, sustainable polymers and plastics, and more efficient methods for future manufacturing.