ELECTROPHYSIOLOGICAL STUDIES OF ACUTE AND CHRONIC ALCOHOL CONSUMPTION

虽然酒精明显会导致心理过程的改变， 也许是因为这些影响是如此之大，如此之普遍， 他们已经证明很难描述。 全球绩效 通常用来记录这种影响的措施， 显然，它们的存在，往往提供很少的信息，以具体的 作用的场所或机制。 本研究旨在解析 酒精对周围神经、感觉、认知和 运动系统使用事件相关的脑电位。 这些 潜力是在性能提供的广泛背景下研究的， 心理生理学、神经心理学、神经放射学和 神经精神病学数据。 酒精的影响在三类受试者中进行了研究：1） 在正常志愿者中检查急性给药的效果， 关于剂量-反应关系、效应的时间过程，以及 与血液酒精水平的关系; 2）脑电活动 研究，结合神经心理学数据，在社交饮酒者中， 试图分析适度饮酒的影响; 3)戒酒者，包括与酗酒有关的精神病患者 研究缺陷的特征，检查短- 和长期的恢复效果，如果有的话，在禁欲，并检查 各种治疗策略的效果。

Although alcohol clearly leads to alterations in mental processes and behavior, it is perhaps because these efects are so great and so pervasive that they have proven difficult to characterize. The global performance measures commonly used to document such effects, while demonstrating clearly their presence, often provide little information as to the specific locus or mechanism of effect. The present research aims to parse the separate effects of alcohol on peripheral nerve, sensory, cognitive and motor systems using event related brain electrical potentials. These potentials are studied within a broad context provided by performance, psychophysiological, neuropsychological, neuroradiological and neuropsychiatric data. The effects of alcohol are investigated in three classes of subjects: 1) The effects of acute administration are examined in normal volunteers with respect to dose-response relationships, the temporal course of effect, and relationship to blood alcohol levels; 2) Brain electrical activity is studied, in conjunction with neuropsychological data, in social drinkers in an attempt to assay the effects of moderate levels of alcohol consumption; 3) Abstaining alcoholics, including those with alcoholism-related mental impairment, are studied to characterize the deficits, to examine the short- and long-term recovery effects, if any, during abstinence, and to examine the efficacy of various treatment strategies.