A regionally strategic NMR spectrometer with globally unique high pressure and reaction monitoring capability

核磁共振波谱是研究分子结构和行为的最有用的方法之一，对于了解我们周围的世界和开发新技术都是至关重要的。它是确定纯化合物的结构、材料的特征和组成以及监测化学反应的强大工具。化学家、材料科学家和生命科学家一直在为从日益复杂的研究成果中提取定性和定量信息而战。核磁共振光谱仪的使用使它们在化学系中无处不在。然而，随着越来越复杂的问题的解决，用标准的核磁共振仪器提取所需的化学信息变得越来越困难。许多光谱要么太复杂，无法分析，要么信号重叠太多，要么信号强度低于检测极限。曼彻斯特迫切需要一种新的高灵敏度、高分辨率的核磁共振光谱仪来支持物理科学的进步。该仪器将在700 MHz的1H频率下运行，具有非常高的分辨率，并将配备一个液氦冷却探头，为液体样品提供非常高的灵敏度和低检测限。它还将有能力研究广泛的固态原子核。光谱仪将集成到一个高压系统中，该系统使化学反应混合物流经仪器，允许实时测量反应物和产品浓度，并提供有关高压反应行为的独特访问信息。该仪器将支持广泛的研究领域，包括催化、化学反应动力学和机理、合成有机化学、合成超分子化学、聚合物材料、储能、功能陶瓷和无机物、核裂变、合成配位化学、合成生物学以及化学生物学和生物化学。拟议中的光谱仪将提供地区战略能力--高灵敏度和高分辨率，针对化学应用进行优化--并支持和补充EPSRC设施和全国高场核磁共振仪器。

Nuclear magnetic resonance (NMR) spectroscopy is one of the most useful methods for studying the structures and behaviours of molecules, and is of critical importance both in understanding the world around us and in developing new technologies. It is a powerful tool for determining the structures of pure compounds, the characteristics and composition of materials, and for monitoring chemical reactions.Chemists, and materials and life scientists, fight a continual battle to extract qualitative and quantitative information from the increasingly complex fruits of their research. The utility of NMR spectrometers has made them ubiquitous in chemistry departments. However, as more and more complex problems are tackled, extracting the chemical information needed is becoming increasingly difficult with standard NMR instrumentation. Many spectra are either too complex to analyse, with too many overlapped signals, or have signal strengths below the detection limit. A new high sensitivity, high resolution NMR spectrometer is urgently needed in Manchester to support advances in the physical sciences. The instrument will operate at a 1H frequency of 700 MHz, giving very high resolution, and will be equipped with a liquid helium-cooled probe, giving very high sensitivity and a low limit of detection for liquid samples. It will also have the capability to study a wide range of nuclei in the solid state. The spectrometer will be integratable into a high pressure system that flows chemical reaction mixtures through the instrument, allowing reactant and product concentrations to be measured in real time and providing unique access to information about high pressure reaction behaviour. The instrument will underpin a broad range of research areas including Catalysis, Chemical Reaction Dynamics and Mechanisms, Synthetic Organic Chemistry, Synthetic Supramolecular Chemistry, Polymer Materials, Energy Storage, Functional Ceramics and Inorganics, Nuclear Fission, Synthetic Coordination Chemistry, Synthetic Biology, and Chemical Biology and Biological Chemistry. The proposed spectrometer will provide regionally strategic capabilities - high sensitivity and high resolution, optimised for chemical applications - and underpin and complement EPSRC facilities and high field NMR instrumentation nationally.