MOLECULAR STUDIES BY SOLID-STATE NMR

我们已经成功地阐明了一个九- 在阿尔茨海默病的淀粉样蛋白中发现的氨基酸肽。 更基本的工作包括开发基本上是CPMAS的东西 TOCSY版本。 我们称这个实验为DICSY， 相关光谱学 其他正在进行的研究包括理论 和演示CPMAS实验i）创建旋转 在定标化学位移偏移处的共振ii）探索偶极 涉及三个核的相互作用和iii）选择性地反转一个 边带流形与另一个核的边带流形重叠。

We have successfully elucidated detailed structural features of a nine- amino acid peptide found in the amyloid protein of Alzheimer's disease. More basic work has included development of what is essentially a CPMAS version of TOCSY. We call this experiment DICSY, for dipolar correlation spectroscopy. Other ongoing research includes the theory and demonstration of CPMAS experiments i) to create rotational resonances at scaled chemical shift offsets ii) to explore dipolar interactions involving three nuclei and iii) to selectively invert one sideband manifold overlapping that of another nucleus.