P.E.T. IN OBSESSIVE-COMPULSIVE AND TOURETTE'S DISORDER

本文详细介绍的研究项目是PET研究 强迫症和精神分裂症这两种主要的相关神经精神疾病 这些 疾病之间不仅有共同的特征， 其他神经精神焦虑情绪和运动障碍 局部脑葡萄糖代谢将进行研究， 氟脱氧葡萄糖（FDG），而多巴胺和5-羟色胺受体 用氟乙基螺哌隆（FES）测量结合。 的 具体目标是确定神经解剖定位 这些表达的生化异常 疾病。 将对六组受试者进行FDG和 FES：1.强迫症无强迫（“纯粹的强迫症”），2。强迫症， 强迫症，3. 没有强迫症症状的TD，4。有强迫症症状的TD， 5. TD亲属与慢性多发性抽动症（CMT）和6。正常人 假设具有纯粹精神症状的受试者（#1） 在FDG和MRI上都有眶回和尾状核异常， FES-PET，而纯运动症状患者（#5）将异常 只在壳核 受试者组#3将具有尾状核， 壳核病理，而#2和#4眶，尾状核和壳核 异常，并且将彼此难以区分。 的 此外，我们亦会检视所收集的资料，以找出其他发现。这些 研究不仅将进一步了解 强迫症和TD的病理生理学异同 (and因此，进一步努力控制这些疾病），但将 也揭示了神经化学解剖组织， 更高的大脑功能。

The research project detailed in specific, herein, is a PET study of two major, related neuropsychiatric diseases, OCD and TD. These diseases share features in common not only with each other, but with other neuropsychiatric anxiety, mood, and movement disorders. Regional cerebral glucose metabolism will be studied with fluorodeoxyglucose (FDG), while dopamine and serotonin receptor binding will be measured with fluoro-ethyl-spiperone (FES). The specific aim is to determine the neuro-anatomical localization of biochemical abnormalities which underlie the expression of these illnesses. Six groups of subject will be studied with both FDG and FES: 1. OCD without compulsions ("pure obsessionals"), 2. OCD with compulsions, 3. TD without OCD symptoms, 4. TD with OCD symptoms, 5. TD relatives with chronic multiple tic (CMT) and 6. normals. It is hypothesized that subjects with purely mental symptoms (#1) will have orbital gyrus and caudate abnormalities on both FDG and FES-PET, while pure motor symptom patients (#5) will be abnormal only in the putamen. Subject group #3 will have caudate and putamen pathology, while #2 and #4 orbital, caudate and putamen abnormalities and will be indistinguishable from each other. The data collected will be inspected for other findings as well. These studies will further understanding not only of the pathophysiological similarities and differences between OCD and TD (and thus further efforts to control these illnesses), but will also shed light on the neuro-chemical-anatomical organization of higher cerebral function.