Constitutive activation of the growth hormone receptor

生长激素调节生长、新陈代谢、骨骼、干细胞和寿命，以及癌症。这些作用是由生长激素受体介导的，在这里，我们试图了解激素是如何通过不同程度地在没有激素的情况下活跃的受体结构来激活它的。我们将用这些来阐明它的信号特性，它促进癌症的能力，生长肌肉的能力，以及巨人症和癌症的病例是否是我们已经确定的激活突变的结果。

Growth hormone regulates growth, metabolism, bone, stem cells and longevity, and cancer. These actions are mediated by the GH receptor, and here we seek to understand how it is activated by the hormone through receptor constructs which are active without hormone, to different degrees. We will use these to elucidate its signaling properties, its ability to promote cancer, to grow muscle, and whether cases of giantism and cancer are a consequence of the activating mutations we have identified.