BIOACCUMULATION OF ENVIRONMENTAL CARCINOGENS--METHODOLOGY AND CHARACTERIZATION

大量研究的证据支持这一理论， 癌症和呼吸道疾病可能是由环境因素引起的。 污染 在具有高风险的区域之间存在良好的相关性。 癌症和呼吸道疾病的发病率以及高水平的 大气污染. 据怀疑，即使是中等水平的空气 污染会增加有害健康的风险。 对大气颗粒物中有机部分的生物测试 显示出诱变和致癌活性。 然而， 试图将特定的健康影响归因于空气的不确定性 由于环境、暴露和 人口 一项研究表明， 人体将为这一理论提供直接证据。 该项目的目的是确定有机大气 污染物可在脂质组织中存款和积累。 分析 能够检测广谱化合物的方法将 首先针对气体样品、颗粒样品和 脂质组织 两个地方的空气，每个地方都有一只猴子 殖民地，将随着时间的推移进行表征。 一个网站是相对 一个是无污染的，另一个是空气污染严重的。 污染 空气中发现的化合物 样本和脂肪组织中的样本可以提供直接证据 环境化合物会影响人类健康

Evidence from numerous studies support the theory that-human cancers and respiratory illnesses can be caused by environmental pollution. There is a good correlation between regions with a high incidence of cancer and respiratory illnesses and high levels of air pollution. It is suspect that even moderate levels of air pollution can increase the risk of detrimental health effects. Biotesting of the organic fraction of atmospheric particulate has shown mutagenic and carcinogenic activity. However there is much uncertainty in trying to attribute specific health effects to air pollution due to variations in environment, exposure and the population. A study which could show atmospheric pollutants in the human body will lend direct evidence to the theory. The purpose of this project is to determine if organic atmospheric pollutants can deposit and accumulate in lipid tissues. Analytical methodology capable of detecting a broad spectrum of compounds will first be optimized for gaseous samples, particulate samples and lipid tissues. The air at two locations, each the site of a monkey colony, will be characterized over time. One site is relatively pollution free while the other has significant levels of air pollution. Correlation between the compounds found in the air samples and those in the lipid tissues could give direct evidence that environmental compounds could affect human health.