Enantioconvergent Multi-Component Reactions.

不对称合成是合成化学的一个分支，与制造单手型分子（即左手或右手形式）有关。本项目的目的是通过实验建立一个不对称合成的新概念，称为对映收敛多组分反应。这将代表一种全新的方法来获取单手材料从混合物的左手和右手的分子。由于一种被称为霍罗原理的统计现象，这种新方法将产生纯度极高的单手材料。以纯形式合成这些左/右旋分子的能力至关重要，特别是对制药工业而言。这是因为生物分子表现出手性，一种化学物质（即药物/药物）的左旋和右旋形式通常与生物体的相互作用非常不同。

Asymmetric synthesis is the branch of synthetic chemistry associated with making molecules in single-handed form (i.e., left-handed or right-handed form). The aim of this project is to experimentally establish a new concept in asymmetric synthesis called enantioconvergent multi-component reactions. This will represent a completely new method for accessing single-handed materials starting from mixtures of left- and right-handed molecules. Thanks to a statistical phenomenon known as the Horeau Principle, this new method will result in single-handed materials in exceptionally high purity. The ability to synthesise these left/right-handed molecules in pure form is vitally important, particularly for the pharmaceutical industry. This is because biological molecules exhibit handedness and the left-handed and right-handed form of a chemical (i.e., a drug/medicine) often interact very differently with living organisms.