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CLINICAL TRIAL OF THROMBOLYSIS IN MYOCARDIAL INFARCATION

CLINICAL TRIAL OF THROMBOLYSIS IN MYOCARDIAL INFARCATION
心肌梗塞溶栓的临床试验
批准号：
3660103
负责人：
JAMES H CHESEBRO
金额：
$30.78万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
1983
资助国家：
美国
项目状态：
已结题
起止时间：
1983-06-30 至 1986-08-31
来源：
https://reporter.nih.gov/project-details/3660103
关键词：
cardiotonic agents cooperative study coronary vasodilator drug adverse effect fibrinolytic agents fibrinolytic therapy heart disorder diagnosis heart imaging /visualization /scanning heart motion human subject human therapy evaluation intracardiac volume myocardial infarct sizing myocardial infarction nitroglycerin radionuclide diagnosis

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中文摘要
翻译
评估溶栓剂在缩小心肌梗死面积和 从而改善心功能和随后的发病率 死亡率。主要终点将是以下期间的总死亡率 上行期。次要端点包括：影响的确定 溶栓治疗对左心室射血分数的影响 怀疑患有完全性与非完全性心肌梗死的患者 梗塞相关动脉的不完全闭塞.时间限制 成功再通包括根据不同途径的不同 给药；以及不良反应的频率和严重性 冠状动脉内和静脉注射溶栓药治疗急性心肌梗塞 急性脑梗塞患者。
英文摘要
Assess the efficacy of a thrombolytic agent in reducing infarct size and thereby improving ventricular function and subsequent morbidity and mortality. The primary endpoint will be total mortality during the follow up period. Secondary endpoints include determination of the: effect of thrombolytic therapy on left ventricular ejection fraction;proportion of patients suspected of having myocardial infarction with complete versus incomplete occlusion of the infarct related artery; time limits for successful reperfusion including differences according to the route of administration; and frequency and severity of adverse effects of intracoronary and intravenous administration of thrombolytic agents in patients with acute infarction.
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