STUDY OF THE LEGACY OF USPHS TUSKEGEE SYPHILIS STUDY

美国公共卫生服务(USPHS)细节曝光 年“塔斯基吉梅毒对黑人男性未治疗梅毒的研究” 1972年的全国性报纸经常被认为是最有影响力的一份 直接导致机构审查委员会成立的力量 (IRBs)保护美国联邦资助的人类受试者 学习。塔斯基吉遗产项目总体上分为五个阶段 项目(即由5项连续、相关但独立的研究组成) 定性和定量数据收集要素相辅相成。这个 关于“是否以及为什么”少数群体的调查的基本概念 (特别是非洲裔美国人)不愿参与生物医学 研究研究是利用定性数据收集方法(重点 小组调查结果和专家访谈调查结果)，以指导 一种量化工具(对文化敏感的问卷)将 允许在非裔美国人中对这个话题进行比较研究， 西班牙裔和白人。第四阶段，如NMOHRC赠款中所述 申请将于这笔拨款的04年，即1988年开始。会的 既有定量的也有定性的，并将 其特点是该项目从东北地区扩大到 对美国几个选定地区的研究。定性的 部分内容将包括在这些其他地区开展重点小组活动 美国；数量部分将由最终分析组成 和对在第二阶段获得的问卷数据的解释 这项研究将於一九八八年六月完成。 鉴于最近1994年美国国立卫生研究院关于纳入妇女和 生物医学研究中的少数人，这个项目对所有人都有意义 生物医学研究人员。塔斯基吉遗产中的第四阶段研究 Project将继续进行与以下方面有很大关联的调查 少数民族健康研究项目，总体上，对于我们的NMOHRC来说，在 很特别。招募足够数量的受试者进入任何临床 学习总是具有挑战性的，而且常常是有问题的。这将是 为招募非裔美国人受试者而进行的复合 猪恐惧因素的遗产(无论它是否实际上是由于 塔斯基吉研究，或者--由于非洲更广泛的社会现实-- 美国人在过去200年中的生活。)对……有可衡量的影响 非裔美国人与白人的招生态度。这项第四阶段研究 将提供有助于加深对关键问题的理解的数据 与非洲裔美国人研究对象的招募有关。

The exposure of the details of U.S. Public Health Service (USPHS) 'Tuskegee Syphilis Study on Untreated Syphilis in the Negro Male' in national newspapers in 1972 is often cited as the most influential single force that directly led to the creation of Institutional Review Boards (IRBs) for the protection of human subjects in U.S. federally-funded studies. In its totality, The Tuskegee Legacy Project is a five Phase project (i.e. consists of 5 sequential, related but separate studies) with complementary qualitative and quantitative data collection elements. The basic concept of this investigation into 'whether and why' minorities (esp. African-Americans) are reluctant to participate in biomedical research studies is to utilize qualitative data gathering methods (focus group findings and expert interview findings) to guide the development of a quantitative instrument (a culturally-sensitive questionnaire) that will allow for a comparative study of this topic across African-Americans, Hispanics and Whites. Phase IV, as described in this NMOHRC grant application will be initiate in Year 04 of this grant, i.e. 1988. It will have both quantitative and qualitative components and will be characterized by the expansion of this project from a Northeast Regional study to a study of several selected regions of the U.S.. The qualitative component will consist conducting focus groups in these other regions of the U.S.; the quantitative component will consist of the final analysis and interpretation of the questionnaire data obtained in the Phase Ill study which will be completed by June 1988. Given the recent 1994 NIH guidelines on the inclusion of women and minorities in biomedical research, this project has significance for all biomedical researchers. This Phase IV study within the Tuskegee Legacy Project will continue a line of inquiry that has great relevance for minority health research projects, in general, and for our NMOHRC, in particular. Recruitment of adequate numbers of subjects into any clinical study is always challenging and often problematic. This would be compounded for the recruitment of African-American subjects if the 'guinea pig fear factor' legacy (regardless of whether it is, in fact, due to the Tuskegee Study, or--due to the broader societal realities for African- Americans over the last 200 years in the U.S.) has a measurable impact on enrollment attitudes of African-Americans vs Whites. This Phase IV study will provide data that will enhance understanding of the critical issues related to the recruiting of African-American research subjects.