MULTICENTER AIDS COHORT STUDY

这项旨在帮助艾滋病研究工作的研究(SHARE)于1983年由 国家过敏症和传染病研究所和国家 癌症研究所。从一开始，巴尔的摩的研究就是 与匹兹堡、芝加哥和洛杉矶的临床站点密切协调 安吉。由此产生的四个临床站点之间的合作， 美国国家卫生研究院和数据中心的调查人员后来被称为 多中心艾滋病队列研究(MACS)。Mac被设计成一项研究 艾滋病的危险因素和进展的自然历史。 研究开始后不久，艾滋病毒(当时称为HTLV-III/LAV) 因此，这项研究成为艾滋病毒的自然历史研究 感染。自那以后，参与者至少每六个月就会出现一次 1984年4月开始招生。面试者管理的调查问卷 在每一家诊所都进行了集中的体检 参观。标本(包括血清、血浆和冷冻保存的外周血 血液单个核细胞)在每次访问时都被收集并存储在 全国性和地方性的资料库。 最初的队列由1153名同性恋/双性恋男性组成，他们是 1984年4月至10月招募。在这些人中，30%的人艾滋病毒血清呈阳性 在基线和104名基线血清阴性参与者中 血清转换。1987年重新开始招聘，以便招募 现任参与者和少数族裔男同性恋者的伴侣。240个 更多的参与者加入了这项研究，其中一半是非洲裔美国人。 在新招募的队列中，感染率为50%。 基线。从互委会的自然历史研究中，我们了解到 感染的危险因素和未经治疗的自然病史 治疗艾滋病毒感染。 免疫学、病毒学、人类白细胞抗原相关和行为因素 与艾滋病毒感染持续时间延长或缩短有关的有 在整个互委会范围内受到热烈追查，并与来自 许多不同的机构。病毒学和生物信息学研究 进行性艾滋病毒感染的免疫病理机制是至关重要的领域 将在其他应用程序中解决。此应用程序提供 支持基础设施继续临床和 对队列进行流行病学跟踪，并促进合作 与Mac内外的板凳科学家一起工作。 HIV相关的临床谱系的完整描述 精神障碍也是未来研究的一个重要领域。这 研究将包括：流行病学、营养和行为因素 与延长生存时间和延续神经心理状态有关 准确描述已处理和未处理的自然历史的研究 这些疾病与艾滋病毒感染有关。因此，队列的随访 艾滋病后重要后果的成员，如所有与艾滋病毒有关的成员 感染、其他感染、恶性肿瘤和神经心理事件 而生存也成为研究的主要焦点。

The Study to Help the AIDS Research Effort (SHARE) was funded in 1983 by the National Institute of Allergy and Infectious Diseases and the National Cancer Institute. From the beginning, the research in Baltimore was closely coordinated with the clinical sites in Pittsburgh, Chicago and Los Angeles. The resulting collaboration between the four clinical sites, investigators at the NIH and the data center became known as the Multicenter AIDS Cohort Study (MACS). The MACS was designed to be a study of the natural history of risk factors for and progression toward AIDS. Shortly after the study began, HIV (known then as HTLV-III/LAV) was discovered, thus making the study a natural history study of HIV infection. Participants have been seen at least every six months since enrollment began in April 1984. An interviewer-administered questionnaire and a focused physical examination have been performed at each clinical visit. Specimens (including serum, plasma, and cryopreserved peripheral blood mononuclear cells) have been collected at each visit and stored in both national and local repositories. The initial cohort in SHARE consisted of 1,153 gay/bisexual men who were recruited from April to October 1984. Of these, 30% were HIV seropositive at baseline and 104 of the baseline seronegative participants seroconverted. Recruitment was reopened in 1987 in order to recruit partners of current participants and minority gay men. Two hundred forty more participants joined the study, half of whom are African Americans. The prevalence of infection in the newly recruited cohort was 50% at baseline. From the natural history studies in the MACS, we have learned risk factors for infection and the natural history of untreated and treated HIV infection. Immunological, virological, HLA-associated and behavioral factors that may be associated with prolonged or shortened duration of HIV infection are being hotly pursued MACS-wide and in collaboration with investigators from many different institutions. Research into the virological and immunopathological mechanisms of progressive HIV infection are vital areas to be addressed in other applications. This application provides the support for the infrastructure to continue the clinical and epidemiological follow-up of the cohort and to facilitate collaboration with bench scientists both inside and outside of the MACS. A complete description of the clinical spectrum of HIV-associated disorders is also an important area of research for the future. This research will include: epidemiological, nutritional and behavioral factors associated with prolonged survival, and continuing the neuropsychological studies to accurately describe the treated and untreated natural history of these disorders in HIV infection. Therefore, follow-up of cohort members for important post-AIDS outcomes, such as all HIV-related infections, other infections, malignancies, and neuropsychological events and survival is become a primary focus of the study.