Control of pathogenic antibody responses in humans

缺乏或不适当的抗体反应是许多自身免疫性疾病、过敏、食物不耐受的核心，并经常解释疫苗接种策略的失败。专门的滤泡T细胞控制着B细胞产生的抗体的质量。该项目将结合研究人类B细胞辅助细胞或调节性滤泡T细胞的基础研究，以及确定自身抗体驱动疾病病因的基因研究。研究结果将揭示靶向治疗方法。

Deficient or inappropriate antibody responses are at the core of many autoimmune diseases, allergies, food intolerances, and often explain the failure of vaccination strategies. Specialised follicular T cells control the quality of antibodies produced by B cells. This fellowship will combine basic studies investigating B cell helper or regulatory follicular T cells in humans with genetic studies identifying the causes of autoantibody-driven diseases. The results will uncover targeted therapies.