HORMONES, HORMONE RECEPTORS, AND AGING--HORMONE REPLACEMENT IN MENOPAUSAL WOMEN

在一项对30名65-75岁的健康女性进行的为期2年的研究中， 每日口服雌激素和低剂量雷公藤多甙比较 30名年龄匹配的未接受ERT的女性BLSA参与者中， 完成一年治疗的受试者显示， 抑郁、愤怒和紧张，由情绪量表测得 （n=18），血管扩张症状显著减轻。16完成 第二年，全身骨骼显著增加， 矿物质密度（3个梅花减去7%）和腰椎密度（7个梅花减去7%） 1%），与骨吸收生物标志物减少相关 包括尿吡啶酚（30 ± 6%）和血清骨钙素 (35正负6%）。此外，在整体上亦有显著下降。 胆固醇（6 ± 2%）和LDL胆固醇（14 ± 3%）， HDL胆固醇增加（9 ± 4%）。 不利影响 包括乳房肿胀、压痛和阴道斑点， 从3个月时的平均2.3 ± 1.3天/月降至0.3  .2天/月，1年。 对骨骼、血脂和情感的积极影响 和最小的副作用，建议老年妇女应包括在内， 在未来的绝经后妇女使用雌激素的随机临床试验中， 妇女 在一项关于激素调节变化的纵向研究中， 和矿物质代谢以及糖脂代谢 在绝经过渡期，87名妇女共完成了297项 GCRC门诊访视范围为1 - 11次访视/人。 八 女性完成了12次GCRC住院访视， 取样. 比较内分泌特征的横断面数据分析 骨生物化学、骨密度测量和身体 1995年8月开始进行人员组成评估。

In a study of 30 healthy women 65-75 years of age treated for 2 y with constant combined daily oral estrogen and low dose progestin compared with 30 age-matched female BLSA participants who do not receive ERT, 18 treated subjects completing one year showed significant decreases in depression, anger, and tension as measured by the Profile of Mood Scale (n=18), and significant decreases in vasomotor symptoms. In 16 completing the second year, there were significant increases in total body bone mineral density (3 plum minus 7%), and lumbar spine density (7 plum minus 1%) which correlated with decreases in biomarkers of bone resorption including urinary pyridinoline (30 plus minus 6%) and serum osteocalcin (35 plus minus 6%). There were also significant decreases in total cholesterol (6 plus minus 2%) and LDL cholesterol (14 plus minus 3%)and increases in HDL cholesterol (9 plus minus 4%). Adverse effects included breast swelling and tenderness and vaginal spotting which decreased from a mean of 2.3 plus minus 1.3 days/mo at 3 months to 0.3  .2 days/mo by 1 year. The positive effects on bone, lipids, and affect and minimal adverse effects, suggest that older women should be included in future randomized clinical trials of estrogen use in postmenopausal women. In a longitudinal study of changes in hormone regulation, bone and mineral metabolism, and glucose and lipid metabolism in healthy women during the menopausal transition, 87 women have completed a total of 297 GCRC outpatient visits ranging from 1 to11 visits per individual. Eight women have completed 12 GCRC inpatient visits for 12 hour nocturnal blood sampling. Cross-sectional data analyses comparing the endocrine profiles to the bone biochemistries, bone density measurements, and body composition assessments were begun in August 1995.