NMR relaxometry for biomedicine and advanced materials: FC-RELAX

该项目旨在通过扩展可作为用户工具的分子动力学模型的广度，更好地利用场循环（FC）弛豫法在生物学，医学和创新材料中的作用。这里包含的建模主题集中在快速FC弛豫法可以提供主要贡献的特定挑战，即MRI造影剂，医疗诊断和电池/超级电容器。这种跨学科的方法刺激了主题领导者之间的紧密联系，以探索从医学应用纳米系统到癌症成像的领域，以及从自旋弛豫理论的发展到生物分子动力学的描述。例如，对复杂系统的弛豫曲线的研究，例如具有多个水池的纳米凝胶、纳米颗粒和纳米材料，将允许表征其流动性，并评估水分子从一个水池到另一个水池的交换率，从而为提高其作为诊断、制药和医疗设备的效率铺平道路。

This project aims to better exploit the role of Field-cycling (FC) relaxometry in biology, medicine and innovative materials by extending the breadth of molecular dynamics models that are available as a tool for the users. The modelling themes included here focus on specific challenges to which Fast FC relaxometry can provide major contributions, namely MRI contrast agents, medical diagnosis and batteries/supercapacitors. This cross-disciplinary approach stimulates strong interconnections between the theme leaders to explore domains ranging from nanosystems for medical applications to the imaging of cancer, and from the development of spin relaxation theories to the description of dynamics of biomolecules. For instance, the investigation of the relaxometry profiles of complex systems, as for instance nanogels, nanoparticles and nanomaterials with multiple water pools, will allow for the characterization of their mobility and for the evaluation of the exchange rate of water molecules from one pool to another, thus paving the way for improving their efficiency as diagnostic, pharmaceutical and medical devices.