Hyperpolarised portable NMR for targeted analytical solutions beyond the laboratory (HYPERSOL)

在科学领域，获取新数据推动创新。颠覆性技术以一种简单、经济的方式提供定量信息，从而改变了研究。例如，考虑基因测序技术对从人类健康到法医的应用的影响。核磁共振波谱是一项强大的技术，它彻底改变了物理和生物科学。然而，标准的核磁共振光谱仪又大又贵，这意味着它们仅限于专用的技术设施。如果检测器可以被带出实验室并带到样品中，则有可能在NMR中产生阶跃变化。挑战是在不牺牲实验室核磁共振的灵敏度和化学分辨能力的情况下实现这一目标。超极化核磁共振解决方案超越实验室（HyperSoL）项目的独特创新是一种将氢和碳的核磁共振响应放大100倍的新方法。该方法通过获取碳和氢的化学信息，提高了便携式核磁共振装置的灵敏度和化学辨别能力。HyperSoL项目将开发两种基于商业和定制核磁共振仪器的方法。这些方法将保持仪器的便携性，同时提高对天然同位素丰度的分析物的灵敏度和化学分辨率。利用这种新的便携式核磁共振技术将把核磁共振从实验室解放出来，改变它在制造、环境监测、法医和现场测试等不同领域的使用方式。成功实现这一愿景所需的基本进展可以由PI独特地提供，PI在通过基础核自旋研究推进核磁共振发展方面拥有国际记录。这笔拨款将为PI提供必要的资源，以巩固她在便携式核磁共振技术开发方面的世界领先地位。

In science, access to new data drives innovation. Disruptive technologies transform research by providing quantitativeinformation in a simple and cost-effective way. Consider, for example, the impact of gene sequencing technology onapplications from human health to forensics. Nuclear magnetic resonance (NMR) spectroscopy is a powerful technique thathas revolutionised the physical and biological sciences. However, standard NMR spectrometers are large and expensive,meaning they are confined to dedicated technical facilities. The potential to generate a step change in NMR exists if thedetector could be taken out of the lab and brought to the sample. The challenge is to achieve this without sacrificing thesensitivity and chemical resolving power of laboratory NMR. The unique innovation of the Hyperpolarised NMR Solutionsbeyond the Laboratory (HyperSoL) project is a new method to amplify the NMR response of hydrogen and carbon by factorsof >1000-fold. By accessing chemical information about carbon as well as hydrogen, this method will enhance both thesensitivity and chemical discrimination of portable NMR devices. The HyperSoL project will develop two approaches basedon both commercial and bespoke NMR instrumentation. These methods will maintain instrument portability, while amplifyingsensitivity and chemical resolution for quantifying analytes at natural isotopic abundance. Harnessing this new portable NMRtechnology will liberate NMR from the laboratory, transforming the way that it is used in such disparate areas asmanufacturing, environmental monitoring, forensics and field testing. The fundamental advances that are required tosuccessfully realise this vision can be uniquely delivered by the PI, who has an international track record in advancing NMRdevelopment through fundamental nuclear spin research. This grant would provide the PI with the necessary resources toconsolidate her position as a world-leader in portable NMR technology development.