BASIC AND APPLIED RESEARCH IN PROTOZOAN DISEASES

由利什曼-锥虫复合体引起的疾病在 西半球 这些疾病在临床上表现出明显的变化， 然而，从分类学、生物化学和免疫学上讲， 保持了许多相似之处，这可能为发病机制提供线索。 控制 这些疾病将由致病机制的仔细评估引起， 抗菌治疗、疾病模式和准确诊断方法。 该项目汇集了基础科学和临床研究人员 来自康奈尔大学医学院和洛克菲勒大学， 来自巴伊亚大学和 巴西利亚大学。 这一合作努力的中心焦点是 基础和应用临床研究的整合。 主要研究领域 包括：1）南美锥虫病基础寄生虫学、免疫生物学和药理学 疾病和利什曼病; 2）临床疾病模式，流行病学和 遗传学这些疾病;和3）免疫技术的应用， 了解发病机制和可靠的诊断。 这项赠款的核心是 试图协调来自不同国家的调查人员的活动， 纪律，允许交换有限的资源，使这些调查人员 与国外的年轻研究人员接触，并增进我们对 重要的人类疾病。

Diseases caused by the Leishmania-Trypanosoma complex are of major importance in the Wester Hemisphere. The diseases exhibit marked variation in clinical manifestations yet, taxonomically, biochemically and immunologically, they maintain many similarities which may provide clues to pathogenesis. Control of these diseases will result from careful evaluation of pathogenic mechanisms, antimicrobial therapy, disease patterns, and methods of accurate diagnosis. This program project brings together basic science and clinical investigators from Cornell University Medical College and The Rockefeller University and respected Brazilian investigators from the University of Bahia and the University of Brasilia. The central focus of this collaborative effort is the integration of basic and applied clinical research. The major research areas include: 1) basic parasitology, immunobiology and pharmacology of Chagas' disease and leishmaniasis; 2) clinical disease patterns, epidemiology and genetics these disease; and 3) application of immunologic techniques for understanding pathogenesis and for reliable diagnosis. Central to this grant is the attempt to coordinate the activities of investigators from different disciplines to allow exchange of limited resources, to bring these investigators in contact with young researchers abroad, and to advance our understanding of important human diseases.