MODELING OF TIME-DOSE RESPONSE OF HUMAN TUMORS AND NORMAL TISSUES

放射治疗的目的是控制肿瘤。 鉴于克隆原 在尽可能短的时间内提供必要的剂量是有意义的。 尽可能的时间，尽可能的有针对性。 限制因素 正常组织反应：正常组织反应必须 不超过“容忍度”。 高分子材料的开发与应用 技术，特别是在计算机和基于计算机的和辅助的 影像学在肿瘤定位和治疗方面取得了巨大进展 规划，甚至在交付技术和质量方面 保证，即，这个问题的空间方面。 关于下列事项的决策 剂量的量及其随时间的分布（通过分次或 然而，延长）仍然基本上是不规则的。 本项目 继续发展和探索的理论描述， 肿瘤和正常组织的时间-剂量反应。 我们的工作 主要研究线性二次模型的推广和应用。 目前，工作重点是研究 来自局部/区域控制的几个肿瘤特征参数 一系列临床分级研究的概率数据。

The purpose of radiation therapy is tumor control. In view of clonogen proliferation it makes sense to deliver the necessary dose in as short a time as possible, and as well-targeted as possible. The limiting factor in tumor treatment is normal tissue reaction: normal tissue reactions must not exceed "tolerance" level. The development and application of high technology particularly in computers and computer based and assisted imaging has stimulated great progress in tumor localization and treatment planning, and even in the technology of delivery and its quality assurance, i.e., the spatial aspects of the issue. Decision-making as to the amount of dose and its distribution over time (by fractionation or protraction) is still essentially empiricle, however. The present project continues the development and exploration of a theoretical description of time-dose response of tumors as well as normal tissues. Our work concentrates on extension and application of the Linear-Quadratic model. Currently, efforts are concentrating on the feasibility of deriving several tumor characteristic parameters from local/regional control probability data from a series of clinical fractionation studies.