Advanced Multiscale Biological Imaging using European Infrastructures

使用欧洲基础设施的先进多尺度生物成像（AMBER）联盟已经组建，用于开发和开发大规模的欧洲基础设施，以解决从分子到细胞到组织、器官和生物体组织水平的生物成像的关键需求。它汇集了广泛的能力，包括临床从业人员，生物和生物医学科学家，物理科学家和设施/基础设施科学家。这一倡议是在科学领域在设施发展、数据管理、数据分析和解释方面发生显著变化的时候提出的。很难想象有一个时代比现在更需要以一种适应和进步的方式将来自不同领域的社区聚集在一起。鉴于将体外生物医学研究与体内和离体结果联系起来的重要性，目前临床科学与基础科学之间的差距是一个巨大的挑战。AMBER联盟和该计划旨在弥合这些领域——在欧洲的中心设施x射线和中子束源以及补充技术取得了巨大的技术和方法发展的时候。人工智能和机器学习方法的应用也出现了爆炸式增长和日益趋同。AMBER将以前所未有的方式汇集并启用医学、生物学和方法论能力，对欧洲下一代研究和下一代研究人员产生深远的潜在影响。工作将包括技术开发，特别是在结合成像技术和数据方面，以提供疾病背景下生命过程的整体图景，以及对具有挑战性的疾病相关样本和系统进行成像，包括离体、体内样本和医疗技术对象、分析和建模。该计划将在生物医学和临床社区之间建立更密切的联系，向所产生的知识的新用户开放研究基础设施。它还将带来高水平的跨学科和多技术专业知识，以及世界领先的基础设施能力，专注于对人类健康具有根本价值的问题。以下承诺合作的机构将带来独特的能力和能力：Lund先进中子和x射线科学研究所（LINXS）， MAX IV实验室，Lund，欧洲散裂源（ESS）， Lund， Laue-Langevin研究所（ILL），莱斯特大学结构和化学生物学研究所，欧洲分子生物学实验室（EMBL）和国际分子机制和机器研究所（IMOL），波兰科学院。

The Advanced Multiscale Biological Imaging using European Infrastructures (AMBER) consortium has been assembled for exploitation and development of large-scale European infrastructures to address key needs for biological imaging over length scales from molecular, through cellular, to tissue, organ and organism levels of organisation. It brings together a wide range of competence including clinical practitioners, biological and biomedical scientists, physical scientists, and facility/infrastructure scientists.This initiative is being made at a time when remarkable changes are occurring on the scientific landscape in terms of facility developments, data management, and data analysis and interpretation. It is hard to imagine a time for which there has been a bigger need to bring together communities from different fields in an adaptive and progressive way. The current gap between clinical and fundamental science is a great challenge given the importance of relating in vitro biomedical research with in vivo and ex vivo results. The AMBER consortium and the programme has been designed to bridge these fields - at a time in which there are massive technical and methodological developments in Europe at central facility X-ray and neutron beam sources, and complementary techniques. There is also explosive growth and increasing convergence in the application of artificial intelligence and machine learning approaches. AMBER will bring together and enable medical, biological, and methodological capabilities in an unprecedented way, with a profound potential impact for Europe's next generationresearch and next generation researchers.Work will include technique development, particularly in terms of combining imaging techniques and data to provide an overall picture of life processes in the context of disease, as well as imaging of challenging disease relevant samples and systems, including ex vivo, in vivo samples and medical technology objects, analysis and modelling. The programme will create closer ties to and between biomedical and clinical communities, opening the research infrastructures to new users of the knowledge generated. It will also bring high level interdisciplinary and multi-technique expertise alongside world-leading infrastructure capability to focus on problems of fundamental value to human health. The following committed partnering organisations will bring in unique competence and capability: The Lund Institute of Advanced Neutron and X-ray Science (LINXS), the MAX IV Laboratory, Lund, the European Spallation Source (ESS), Lund, the Institut Laue-Langevin (ILL), the Institute for Structural and Chemical Biology within the University of Leicester, the European Molecular Biology Laboratory (EMBL), and the International Institute of Molecular Mechanisms and Machines (IMOL), of the Polish Academy of Sciences.