QUANTITATIVE ANALYSIS OF VIRAL GENOMES AND THEIR CLINICAL CORRELATIONS

这是一项持续的努力，以应对日益增长的需求， 更精确地测量任何病毒中的相关基因组信息 感染对特定病毒基因存在的了解将 帮助识别传染源。然而，为了评估 一种疾病，评估治疗的效果，确定 疾病进展的预测因子，并监测 患者的感染进展，一个更精确和定量的 需要对特定基因进行分析。这些以前高度 面向研究的问题，现在可以开始回答先进的 分子生物学技术如聚合酶链式反应（PCR）， 限制性核酸酶消化片段的测序和作图。我们 将这项技术与我们目前正在进行的 临床研究，如B型肝炎病毒、丙型肝炎病毒和艾滋病毒 感染.我们还将改进基本的PCR技术， 定量程序。 我们也在研究基于PCR技术的 基因组分型程序。

This is a continuous effort in responding to the increasing demand for more precise measurement of relevant genomic information in any viral infection. The knowledge of the presence of a specific viral gene will help in identifying the infectious agent. However, to assess the stage of a disease, to evaluate the efficacy of a treatment, to determine the value of a predictor in the progression of a disease and to monitor the patient's progression of an infection, a more precise and quantitative analysis of the specific gene would be required. These previously highly research oriented questions can now begin to be answered with the advanced technology of molecular biology such as polymerase chain reaction (PCR), sequencing and mapping of the restriction nuclease digested fragments. We would apply this technology in conjunction with our current on-going clinical research such as hepatitis B virus, hepatitis C virus and HIV infections. We would also improve the basic PCR technique to become a quantitative procedure. We are also looking into PCR technology based genomic typing procedures.