MODELING OF TIME-DOSE RESPONSE OF HUMAN TUMORS AND NORMAL TISSUES

放射治疗的目的是控制肿瘤。 鉴于克隆原 在尽可能短的时间内提供必要的剂量是有意义的 尽可能找一个合适的时间，尽可能有针对性。 极限 肿瘤治疗中的因素是正常组织反应：正常组织 反应不应超过“容忍”水平。 发展和 高科技的应用，特别是在计算机和计算机 基础成像和辅助成像促进了肿瘤研究的巨大进展， 定位和治疗计划，甚至在技术上， 交付及其质量保证，即，的空间方面， 问题. 关于剂量及其分布的决策 随着时间的推移（通过分馏或延长）， 然而，经验主义。 本项目继续发展， 肿瘤时间-剂量反应的理论描述 以及正常组织。 我们的工作集中在推广和 线性二次模型的应用。 目前，努力 集中于导出几种肿瘤特征的可行性， 来自一系列局部/区域控制概率数据的参数 临床分离研究。

The purpose of radiation therapy is tumor control. In view of clonogen proliferation it makes sense to deliver the necessary dose in as short a time as possible, and as well-targeted as possible. The limiting factor in tumor treatment is normal tissue reaction: normal tissue reactions must not exceed "tolerance" level. The development and application of high technology particularly in computers and computer based and assisted imaging has stimulated great progress in tumor localization and treatment planning, and even in the technology of delivery and its quality assurance, i.e., the spatial aspects of the issue. Decision-making as to the amount of dose and its distribution over time (by fractionation or protraction) is still essentially empirical, however. The present project continues the development and exploration of a theoretical description of time-dose response of tumors as well as normal tissues. Our work concentrates on extension and application of the Linear-Quadratic model. Currently, efforts are concentrating on the feasibility of deriving several tumor characteristic parameters from local/regional control probability data from a series of clinical fractionation studies.