NATURAL HISTORY OF ORAL MANIFESTATIONS OF HIV INFECTION

美国军事人员和家属进行了测试 对人类免疫缺陷病毒(HIV)的血清呈阳性 沃尔特里德陆军医疗中心的体检和治疗。 受试者还被邀请参加一项研究方案，以 研究艾滋病毒感染的自然历史，由沃尔特进行 里德陆军研究所。口腔健康研究部分 由NIDR进行的研究是这项自然历史研究的一部分。 口腔部分记录了口腔疾病的患病率和发病率 与HIV感染阶段有关的病理情况和 系统性疾病。与这些情况相关的风险因素有 也具有口腔表现的特点和作用，早在 研究疾病进展的预测因子或标记物。范围： 重点是粘膜疾病、牙周状况、念珠菌 感染和唾液成分。迄今为止的结果显示 粘膜病变增加，T4细胞计数随病情进展而减少 感染艾滋病毒的人。最常见的粘膜病变是口腔粘膜病变。 念珠菌病和毛状白斑。破坏性牙周病有 在接受检查的受试者中，约有25%的人发生了这种情况。纵向 研究表明，大约30%没有黏膜疾病的人在 入院患者在随访6个月后出现口腔病变。

United States military personnel and dependents who have tested seropositive for the Human Immunodeficiency Virus (HIV) are given medical examinations and treatment at Walter Reed Army Medical Center. Subjects are also invited to participate in a research protocol to study the natural history of HIV infection, conducted by the Walter Reed Army Institute of Research. An oral health research component conducted by NIDR is a part of this natural history study. The oral component documents the prevalence and incidence of oral pathologic conditions in relation to the stage of HIV infection and systemic disease. Risk factors associated with these conditions are also characterized, and the role of oral manifestations as early predictors or markers of disease progression are studied. Areas of emphasis are mucosal diseases, periodontal conditions, candidal infections, and salivary constituents. Results to date show an increase in mucosal lesions as T4 cell counts decrease with progression of HIV disease. The most commonly observed mucosal lesions were oral candidiasis and hairy leukoplakia. Destructive periodontal disease has occurred in about 25 percent of subjects examined. Longitudinal studies showed that about 30% of persons free from mucosal diseases at entry presented with oral lesions after six months of follow-up.