MYOCARDIAL AND VASCULAR FACTORS IN HEART FAILURE

心力衰竭是一种心脏功能异常的综合征， 心肌生物能量学紊乱，神经和 体液循环控制和外周血管紊乱 所有这些都有助于临床病理学和进展 精神紊乱的症状 这个项目探讨了每一种异常现象 在各种实验模型以及心力衰竭患者中， 有助于确定导致生理异常的机制 过程的特征。 先进的技术是许多 实验方案 使用超声波晶体定量 在狗的心室功能是至关重要的两个项目，使用 核磁共振波谱评估心肌能量学是一个关键组成部分， 其中三个项目，测量循环激素激活， 心力衰竭中使用的三个项目，微球血流在 心肌是两个项目中的关键血流动力学变量， 测量去甲肾上腺素动力学、前臂血流和前臂 动脉顺应性是临床建议的关键特征。 这些 研究偏重于药物干预， 通过直接刺激或干扰已知的药理学机制， 受体。 调查人员之间的互动包括分享 技术，共享实验模型，以及快速纳入 从一个项目到另一个项目的实验设计。 的 这些研究的长期目标是深入了解 所有这些病理生理事件的性质， 导致心力衰竭综合征的原因， 对机制的理解将导致诊断敏锐度的提高 和治疗的成功。

Heart failure is a syndrome in which abnormalities in cardiac function, disturbances in myocardial bioenergetics, abnormalities in neural and humoral circulatory control and disturbances in the peripheral vascular tone all contribute to the clinical symptomatology and to the progression of the disorder. This program project explores each of the abnormalities in various experimental models as well as in patients with heart failure to help define mechanisms that contribute to the physiologic abnormality characteristic of the process. Advanced technologies are key to many of the experimental protocols. The use of ultrasonic crystals to quantitate ventricular function in the dog is critical to two of the projects, the use of NMR spectroscopy to assess myocardial energetics is a key component of three of the projects, measurements of circulating hormones activated in heart failure are utilized in three projects, microsphere blood flow in the myocardium is a key hemodynamic variable in two of the projects, and measurements of norepinephrine kinetics, forearm blood flow and forearm arterial compliance are key features of the clinical proposal. These studies lean heavy on pharmacological intervention in order to explore mechanisms by directly stimulating or interfering with known pharmacologic receptors. Interaction among the investigators includes the sharing of technology, sharing of experimental models, and the rapid incorporation of advances from one project into experimental design of other projects. The long-term goal of these studies is to gain insight into the interactive nature of all of these pathophysiologic events that appear to be contributory to the syndrome of heart failure with the hope that an understanding of mechanism will lead to improvements in diagnostic acumen and therapeutic success.