Cryo-EM inspired drug discovery to treat human fungal pathogenic infections

侵袭性真菌感染是全球人类健康的主要威胁。这些疾病在免疫系统受损的患者(例如艾滋病毒、癌症或器官移植患者)中非常普遍。越来越令人担忧的是，对用于治疗这些感染的四种药物家族中的至少一种产生抗药性的新真菌感染菌株的出现。在这里，我们将创造新的疗法来阻断一种酶的活性，这种酶的活性对这些病原体的生存至关重要。

Invasive fungal infections are a major threat to global human health. These are highly prevalent in patients whose immune system is compromised (e.g. HIV, cancer or organ transplant patients). Of growing concern is the rise of new strains of fungal infections that are resistant to at least one of the four drug families being used to treat these infections. Here, we will create new therapeutics that block the activity of an enzyme whose activity is essential for the survival of these pathogens.