THE ROLE OF SUBCLINICAL INFECTION AND CYTOKINES IN PRETERM PARTURITION

该项目的目标是改进诊断和治疗 胎儿疾病。重点放在先天性心脏病的产前诊断上 非侵入性方法的异常(例如，高分辨率超声和 彩色多普勒血流图)。 该实验室最重要的贡献是表现出 首例成功的人类胎儿内窥镜手术。 采用经腹薄壁胎儿内窥镜确定并结扎胎盘。 无心双胞胎的脐带。此过程代表了一种新的 探讨胎儿疾病的治疗方法。我们预计那名特工 胎儿镜检将在其他疾病的治疗中发挥作用，如 单绒毛膜双胞胎先天畸形，双胞胎对双胞胎 输血综合征、带蒂胎儿肿瘤和其他胎儿和 胎盘状况适合外科治疗。 该实验室使用诊断超声波进行产前诊断。 迄今未诊断出的情况(即 脐带)。对胎儿血流动力学系统的深入研究 早产和胎儿宫内发育迟缓患者 进步了。这些研究的目标是开发非侵入性方法。 评估危重胎儿的心脏功能。

The objective of this project is to improve the diagnosis and treatment of fetal disease. Focus is placed on the prenatal diagnosis of congenital anomalies with non-invasive methods (i.e., high resolution ultrasound and Doppler color flow mapping). The most significant contribution of the laboratory was the performance of the first successful endoscopic surgical procedure in the human fetus. Transabdominal thin-gauge fetoscopy was used to identify and ligate the umbilical cord of an acardiac twin. This procedure represents a new approach to the treatment of fetal disease. We anticipate that operative fetoscopy will have a role in the treatment of other conditions such as monochorionic twins discordant for congenital anomalies, twin to twin transfusion syndrome, pedunculated fetal tumors and other fetal and placental conditions amenable to surgical treatment. The laboratory used diagnostic ultrasound to establish prenatal diagnosis of conditions heretofore undiagnosed (i.e., velamentous insertion of the umbilical cord). Intensive studies of the fetal hemodynamic system in patients with preterm labor and intrauterine growth retardation progressed. The goal of these studies is to develop non-invasive methods to assess cardiac function in the critically ill human fetus.