SCOR IN CORONARY AND VASCULAR DISEASES

杜克大学医学中心缺血性心脏病专科 研究中心是一个多学科、跨部门的临床和 旨在减少死亡和残疾的研究方案 死于缺血性心脏病。该项目的重点是生物医学 工程学、生物统计学、医学、病理学、药理学、 研究问题的生理学、放射学和外科方法 旨在加深我们对病理生理学的理解 缺血性心脏病的基础与优化诊疗 缺血性心脏病患者的比例。为了实现这些目标，我们有 开发了一项合作努力，涉及来自 生物工程、社区和家庭医学系、计算机 科学、医学、病理学、药理学、生理学、放射学和 手术。临床部分包括对每一个 缺血性心脏病的主要表现：急性心肌梗死 梗塞、心绞痛、充血性心力衰竭、心律失常和 心源性猝死。基本组成部分包括研究 蛋白质的分子生物学，它在蛋白质的调节中起关键作用 心肌细胞功能和对血管张力的控制是必不可少的 以加深对缺血的病理生理基础的认识。 研究也针对生理学和生化研究。 这将进一步加深我们对缺血的病理生理学的理解 治疗药物在这种环境中的过程和药理作用。 这一综合努力旨在将我们的研究结果转化为 关于病理生理学、诊断和预后评估，以及 将内科和外科治疗引入诊所，以减少死亡和残疾 死于缺血性心脏病。

The Duke University Medical Center Ischemic Heart Disease Specialized Center of Research is a multidisciplinary, interdepartmental clinical and research program that is directed at the reduction of death and disability from ischemic heart disease. The program focuses on biomedical engineering, biostatistical, medical, pathological, pharmacological, physiological, radiological and surgical approaches to research questions that are directed at furthering our understanding of the pathophysiologic basis of ischemic heart disease and optimizing the diagnosis and treatment of patients with ischemic heart disease. To attain these goals, we have developed a collaborative effort that involves scientists from the Department of Bioengineering, COmmunity and Family Medicine, Computer Science, Medicine, Pathology, Pharmacology, Physiology, Radiology, and Surgery. The clinical components encompasses research into each of the major manifestations of ischemic heart disease: acute myocardial infarction, angina pectoris, congestive heart failure, arrhythmias, and sudden cardiac death. The fundamental component encompasses research into the molecular biology of proteins that play a key role in the modulation of myocardial cell function and control over vascular tone that are essential to furthering our understanding of the pathophysiologic basis of ischemia. Research is also directed towards the physiologic and biochemical studies that will further our understanding of the pathophysiology of the ischemic process and pharmacologic action of therapeutic agents in this setting. This integrated effort is aimed at translating the results of our research concerning pathophysiology, diagnostic and prognostic evaluation, and medical and surgical therapy into the clinic to reduce death and disability from ischemic heart disease.