YALE SKIN DISEASE RESEARCH CORE CENTER

这个应用程序请求为建立耶鲁皮肤组织提供资金 疾病研究核心中心(YSDRC)，它将汇集一个 由25名独立调查人员组成的协作、多学科小组(AS 以及19名其他协理调查员和顾问) 皮肤科、生物学、心脏生物学、比较科 医学、内分泌学、人类遗传学、免疫生物学、分子 生物物理学和生物化学，肿瘤学，病理学，儿科学，药理学， 整形外科、肺部医学和治疗放射学，所有共享 致力于促进对该病病因和发病机制的了解 皮肤病通过正常和病理两方面的调查 皮肤的结构和功能。YSDRC的研究活动将集中在 围绕三大主题：T细胞淋巴瘤和生理性T细胞：皮肤 相互作用；黑素细胞和黑色素瘤的生物学；以及 正常和恶性角质形成细胞的分化。三个核心单元， 每个与耶鲁大学其他资源设施互动的机构将被建立： 分子分析；细胞培养；组织获取和 分布/生物结构和功能。YSDRC 试点/可行性计划将促进新的 通过要求项目进行跨学科皮肤相关调查 涉及调查人员之间的实质性协作，具有互补性 兴趣。YSDRC浓缩项目提供了多个机会 开展新的国家和机构合作研究。这些 因此，每个设施/项目都将有助于实现YSDRC的 主要目标是创造一个环境，大大扩大我们的 了解基本的皮肤生物学以及对多种皮肤疾病的了解 皮肤病。为了实现这一目标，YSDRC的具体目标是 要：1)激发新的多学科互动；2)激发新的 参与YSDRC一个或多个研究领域的调查人员；3) 通过以下方式利用潜在的重要新研究机会 跨学科试点/可行性项目；4)组织耗时的、 将昂贵的技术和程序转化为具有成本效益的核心设施 多人使用；5)提供丰富的培训环境； 6)促进国家和国际合作。

This application requests funding for the establishment of the Yale Skin Disease Research Core Center (YSDRC), which will bring together a collaborative, multidisciplinary group of 25 independent Investigators (as well as 19 other Associate Investigators and Consultants) based in the departments/divisions of Dermatology, Biology, Cardiobiology, Comparative Medicine, Endocrinology, Human Genetics, Immunobiology, Molecular Biophysics and Biochemistry, Oncology, Pathology, Pediatrics, Pharmacology, Plastic Surgery, Pulmonary Medicine, and Therapeutic Radiology, all sharing a commitment to advancing understanding of the etiology and pathogenesis of skin diseases through investigation of both the normal and pathologic structure and function of skin. YSDRC research activities will center around three major themes: T cell lymphoma and physiologic T cell:skin interactions; the biology of melanocytes and melanoma; and the growth and differentiation of normal and malignant keratinocytes. Three Core units, each interacting with other Yale resource facilities will be established: Molecular Analysis; Cell Culture; and Tissue Acquisition and Distribution/Biological Structure and Function. The YSDRC pilot/feasibility program will enhance the development of new interdisciplinary skin-related investigation by requiring that projects involve substantive collaboration between investigators with complementary interests. The YSDRC enrichment program provides multiple opportunities to develop new national as well as institutional collaborative studies. These facilities/programs will thus each contribute to achieving the YSDRC's principal goal of creating an environment which will greatly amplify our understanding of basic cutaneous biology as well as of a broad variety of skin diseases. To achieve that goal, the specific aims of the YSDRC are to: 1) stimulate new multidisciplinary interactions; 2) stimulate new investigators to become involved in one or more areas of YSDRC research; 3) capitalize on potentially important new research opportunities through interdisciplinary pilot/feasibility projects; 4) organize time-consuming, expensive techniques and procedures into cost-efficient core facilities used by multiple investigators; 5) provide a rich training environment; and 6) foster national and international collaborations.