COLLABORATIVE ALCOHOL-RELATED LONGITUDINAL PROJECT

要求继续支持与酒精有关的 纵向项目--一个最初于1987年4月1日资助的3年项目-- 其总体目标是评估 关于酒精消费的流行病学和解释性研究， 问题 该项目收集了原始数据（以标准化的 格式）来自41个纵向数据集，代表15个国家， 多学科的合议庭，以测试在酒精研究的关键假设。 建立与酒精有关的合作组织的理由 纵向项目是基于系统地 确定纵向研究的结果在多大程度上可以 在不同年龄组、历史时期或文化中复制， 描述和预测饮酒模式和问题。 研究 问题是围绕一个探讨相互关系的模型组织的 饮酒模式和问题，实际年龄，文化， 历史 该项目涉及五个广泛的研究议程：（1） 饮酒模式和问题的流行率、发生率和长期性 以确定这些模式是否一致 跨数据集，独立于出生队列的影响， （2）外源性因素--生物因素， 心理学和社会学-在年龄层内进行检查，以确定 发起和改变跨队列饮酒生涯的因素，历史 （3）成人饮酒问题是根据一个 最初在儿童时期测量的因素的社会行为模型， 青春期 特别是，该分析旨在确定 在多大程度上“反社会的年轻行为”是一个一致的预测os 成人饮酒问题的数据集，包括重大的历史 （4）成人饮酒问题的研究， 根据父母饮酒和酒精问题使用被收养人和一般 人口设计 使用被收养者研究，假设的跨- 评估世代生物联系是否存在可能的选择偏倚， 队列效应;使用一般人群研究， 父母饮酒习惯和生活过程中的其他因素进行了测试。 跨学科团队研究这两个问题，在两个问题之间建立联系。 （5）对问题的不同方法;（5）总体水平的影响 作为个体饮酒水平变化的潜在解释因素 通过多项纵向研究评估行为。 要求为主要分析阶段提供支助的理由如下： 重申该项目的科学重要性，（B）证明 记录、协调和分析41个纵向数据的任务 集，同时，涉及重大的破土动工和劳动- 初期资金不足的密集工作 完成原始申请的实质性目标，以及（c） 论证了分析的科学性和实用性 迄今为止已经完成了。

Continued support is requested for the Collaborative Alcohol-Related Longitudinal Project--a 3 year project originally funded April 1, 1987-- which has the overall objective of evaluating the replicability of epidemiological and explanatory research on alcohol consumption and problems. The project has assembled primary data (recorded in standardized format) from 41 longitudinal data sets, representing 15 countries, with a multidisciplinary collegium to test critical hypotheses in alcohol studies. The rationale for establishing the Collaborative Alcohol-Related Longitudinal Project was based on the critical need to systematically determine the extent to which results from longitudinal studies can be replicated across age cohorts, historical periods, or culture in the description and prediction of drinking patterns and problems. The research questions are organized around a model which explores interrelationships between drinking patterns and problems, chronological age, culture, and history. Five broad research agendas are addressed by the project: (1) The prevalence, incidence and chronicity of drinking patterns and problems by age and sex are examined to determine if these patterns are consistent across data sets, and independent of the effects of birth cohort, historical period and culture; (2) Exogenous factors--biological, psychological and sociological--are examined within age strata to identify factors which initiate and alter drinking careers across cohorts, history and culture; (3) Adult drinking problems are examined on the basis of a socio-behavioral model of factors originally measured in childhood and adolescence. In particular, this analysis is designed to determine the degree to which "antisocial youthful behavior" is a consistent predictor os adult drinking problems across data sets including significant historical and cultural variation; (4) Adult drinking problems are examined on the basis of parental drinking and alcohol problems using adoptee and general population designs. Using adoptee studies, the hypothesized inter- generational biological link is assessed for possible selection bias and cohort effects; using general population studies, the interaction of parental drinking practices and other factors in the life course is tested. Interdisciplinary teams work on both questions, forging a link between two disparate approaches to the subject; (5) The impact of aggregate-level factors as potential explanations for change in individual level drinking behavior is assessed across multiple longitudinal studies. The request for support for the major analysis phase is justified by (a) reiterating the project's scientific importance, (b) demonstrating that the task of recoding, coordinating, and analyzing the 41 longitudinal data sets, simultaneously, has involved significant ground breaking and labor- intensive work for which the initial period of funding has been inadequate to complete the original application's substantive goals, and (c) demonstrating the scientific and pragmatic significance of the analyses which have been performed to date.