POST-TRANSFUSION HEPATITIS (PTH) IN OPEN HEART SURGERY PATIENTS

本研究调查了输血后肝炎（PTH）的发病率 在前瞻性随访的心脏直视手术患者中， 禁止传染性献血者的措施。 这些措施包括 连续检测供体的丙氨酸氨基转移酶（ALT）、抗体 抗人类免疫缺陷病毒（抗HIV-1）、抗B型肝炎抗体 核心抗原（抗HBc）和丙型肝炎病毒抗体（抗HCV）， 以及捐助者对高风险行为的密集询问。 在1985年至1990年期间，肝炎发病率从10%下降到 约3%。 预计水平将下降到1%之间 2%的人接受了抗HCV检测。 评价 后者目前正在进行中。 超过95%的PTH被归类为 非甲、非乙型肝炎，其中约90%与HCV有关。 由于NIH心脏直视手术项目的关闭，这些研究 乔治敦大学医院（Georgetown University Hospital，GUH）

This study investigates the incidence of post-transfusion hepatitis (PTH) in prospectively followed open-heart surgery patients following a variety of measures to interdict infectious donors. These measures have included sequential testing of donors for alanine aminotransferase (ALT), antibody to the Human Immunodeficiency Virus (anti-HIV-1), antibody to hepatitis B core antigen (anti-HBc) and antibody to the hepatitis C virus (anti-HCV) as well as intensive donor questioning in regard to high-risk behavior. Between 1985 and 1990, hepatitis incidence has fallen from 10% to approximately 3%. It is anticipated that levels will fall to between 1% and 2% following the introduction of anti-HCV testing. Evaluation of the latter is currently in progress. Greater than 95% of PTH is classified as non-A, non-B hepatitis and approximately 90% of this is HCV related. Because of closure of the NIH open heart surgery program, these studies are being conducted at Georgetown University Hospital (GUH).