PATHOPHYSIOLOGIC & BIOCHEMICAL CHANGES OF THERMAL INJURY

热损伤的病理生理学显然是一个连续的相互作用 局部（烧伤）病理学和全身器官功能障碍之间的关系， 需要研究持续性伤害的综合概况。 这些 研究被设计为首先识别伤口中的特定反应， 以及全身性的，这只能通过早期的药理学改变， 干预 通过使用以下方法定义早期生理性伤口反应： 皮瓣腔室模式，血管反应性，毛细血管通透性， 基质改变和伴随的化学变化（烧伤创面液 烧伤创面的原因是什么？ 高血糖症和随后的心肌抑制预计 决定了可能的治疗干预的有效性。 第二，地方 和全身清除剂、阻断剂或增强治疗将被完成 通过设计脂质体或配体药物递送系统， 定量控制效果。 第三，通过控制早期病理生理事件， 早期手术切除烧伤， 覆盖范围，我们预计消除二次级联事件 持续的系统故障 最近在舞台上开发的 将进一步开发体外同种中厚皮肤移植物， 用于中度受伤（低于10%）和严重烧伤 烧伤（大于30%）。

The pathophysiology of thermal injury is clearly a sequential interaction between local (burn wound) pathology and systemic organ malfunction that requires study of an integrated profile of continuing injury. These studies are designed to first identify specific responses in the wound as well as systemically, that can be altered only by early pharmacologic intervention. Defining the early physiologic wound responses by the use of the skin flap chamber mode, vascular reactivity, capillary permeability, matrix alteration, and the accompanying chemical changes (burn wound fluid analysis) in the burn wound, and the cause of the immediate systemic hyperglycemia and the subsequent myocardial depression is expected to dictate effective the probable therapeutic interventions. Secondly, local and systemic scavenger, blockers or enhancing therapy will be accomplished by the design of liposomal or ligand drug delivery systems for quantitatively controlled effect. Thirdly, by controlling the early pathophysiologic events coupled with early surgical removal of the burn injury and immediate, permanent coverage, we anticipate eliminating secondary cascade of events perpetuating systemic malfunction. The recently developed on stage in vitro homologous split thickness skin graft will be further developed and employed in both moderate injuries (less than 10%) and in major burn injuries (greater than 30% burns).