T CELL RESPONSES IN BONE MARROW TRANSPLANTATION

担心功能有效的T细胞库可能永远不会 在MHC不匹配的骨髓移植的背景下发展是基于 对小鼠骨髓中观察到的体内缺陷性T细胞应答的影响 在MHC不同菌株之间构建的嵌合体。无能是 不是由于先天性T细胞缺陷，而是由于 T细胞的特异性，使得这些MHC决定簇被识别为 自身（宿主型）不被抗原呈递细胞表达， 是捐赠者的类型。因此，T细胞对抗原的反应是有缺陷的。 为了评估小鼠和人的T细胞成熟是否相当， 灵长类动物恒河猴的T细胞反应的发展， 研究了T细胞恢复的生物学首先在2008年进行了研究。 T细胞耗尽的自体骨髓移植后的动物。的 CD4+ T细胞重建的时间过程和CD4 + T细胞重建的时间过程 体内T细胞免疫活性的发展，如通过以下能力所定义： 对器官同种异体移植的反应与输注的T细胞数量相关 在骨髓中，与骨髓细胞剂量或 造血重建，增加了残留的T细胞 在输注的T细胞耗尽的骨髓中， 产生后续的T细胞群体。这将意味着 骨髓移植灵长类动物中T细胞的产生可能与骨髓移植灵长类动物中T细胞的产生不同。 鼠标

Concerns that a functionally effective T cell repertoire might never develop in the setting of MHC-mismatched marrow transplantation are based on defective T cell responses in vivo observed in murine bone marrow chimeras constructed between MHC disparate strains. The incompetence is not due to inherent T cell defects, but rather to the restriction specificities of the T cells such that those MHC determinants recognized as self (host type) are not expressed by the antigen presenting cells which are of donor type. The T cell response to antigen is therefore defective. To evaluate whether T cell maturation is comparable in mouse and man, the development of T cell responses in a primate, the rhesus monkey, has been studied. The biology of T cell recovery has first been investigated in animals following T cell depleted autologous marrow transplantation. The time course of CD4+ T cell reconstitution and the time course of the development of in vivo T cell immunocompetence as defined by the ability to respond to an organ allograft correlated with the number of T cells infused in the marrow, and did not correlate with marrow cell dose or with time of hematopoietic reconstitution, raising the possibility that residual T cells in the infused T cell depleted marrow played a central role in the generation of subsequent T cell populations. This would imply that the generation of T cells in marrow grafted primates may not be the same as in the mouse.