ID OF GENES DIFFERENTIALLY EXPRESSED IN DEVELOPING EMBRYONIC LIMB BUDS

基因的阐明和表征 形态发生过程中的纹样形成及其研究 他们的监管是许多方面的核心问题 脊椎动物生物学。可以预期的是，包括 对营养刺激的反应，细胞间的相互作用，迁移， 差异细胞增殖、程序性细胞死亡等 都牵扯进来了。其中许多相同的过程被概括为 在肿瘤形成过程中的一种病理方式。雏鸡的肢体发育是 一种研究花纹分子基础的吸引人的系统 在形态发生过程中形成的。级别的关键事件 参与图案形成的组织/细胞相互作用 在这个有机体中有很好的特征，事件调节 图案的形成似乎总体上与 哺乳动物系统，并有可能分离肢芽组织 从确定的发展阶段中大量产生。这就是我们的目标 这个分离调控基因的长期项目 鸡胚胎肢芽的形态发生。

The elucidation and characterization of genes necessary for establishing pattern formation during morphogenesis and the study of their regulation are problems which are central to many aspects of vertebrate biology. It may be expected that processes including responses to trophic stimuli, cell-cell interactions, migration, differential cell multiplication, programmed cell death, etc. are all involved. Many of these same processes are recapitulated in a pathologic manner during oncogenesis. Chick limb development is an attractive system for studying the molecular basis for pattern formation during morphogenesis. Critical events at the level of tissue/cellular interactions involved in pattern formation have been well characterized in this organism, the events regulating pattern formation appear to be overall very similar to those in mammalian systems, and it is possible to isolate limb bud tissue from defined stages of development in large numbers. It is the aim of this long-term project to isolate genes that regulate morphogenesis in the chick embryo limb bud.