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IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES

IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
裂殖子侵入红细胞受体的鉴定
批准号：
3818147
负责人：
L H MILLER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3818147
关键词：
Plasmodium Plasmodium falciparum Plasmodium knowlesi Pongidae cellular immunity communicable disease transmission disease /disorder model erythrocyte membrane erythrocytes human tissue malaria malaria vaccines membrane activity membrane proteins microorganism immunology mutant protozoal antigen receptor surface antigens virulence

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中文摘要
翻译
裂殖子以受体特异性方式与受体相互作用。 红细胞表面，是免疫力可以对抗的阶段， 阻止入侵。 因此，裂殖子表面成分是 由于它们在红细胞识别中作用和作为抗原 以诱导保护性免疫。 我们正在识别P。 与猴和人红细胞结合的诺氏受体 和恶性疟原虫的蛋白质， 裂殖子和红细胞之间的联系 我们在研究一种抗原 在裂殖子表面，经历抗原变异， 了解这种变异的分子基础。 我们 试图将恶性疟原虫作为动物模型应用于亚灵长类动物 用于疫苗试验。
英文摘要
The merozoite interacts in a receptor specific manner with the erythrocyte surface and is the stage against which immunity may work to block invasion. Thus, merozoite surface components are of interest for their role in erythrocyte recognition and as antigens for induction of protective immunity. We are identifying P. knowlesi receptors for attachment to monkey and human erythrocytes and P. falciparum proteins that are involved in the junction between merozoites and erythrocytes. We are studying one antigen on the merozoite surface that undergoes antigenic variation to understand the molecular basis for this variation. We are attempting to adapt P. falciparum to subprimates as an animal model for vaccine trials.
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IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
IDENTIFICATION OF RECEPTORS FOR MEROZOITE INVASION OF ERYTHROCYTES
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