T CELL RESPONSES IN BONE MARROW TRANSPLANTATION

担心功能有效的T细胞库可能 在MHC-micmatched骨髓的环境中不会发生 移植是基于体内有缺陷的T细胞应答 在小鼠骨髓嵌合体中观察到， 不同的菌株 免疫功能不全不是由于先天性T细胞 缺陷，而是T细胞的限制特异性 这样，那些被认为是自身（宿主类型）的MHC决定簇被 不被供体的抗原呈递细胞表达 类型. 因此，T细胞对抗原的反应是有缺陷的。 到 评估小鼠和人的T细胞成熟是否相当， 灵长类动物恒河猴T细胞反应的发展 猴子已经被研究过了。 T细胞恢复的生物学首先 在T细胞耗尽的自体移植后的动物中进行了研究 骨髓移植 CD 4 + T细胞的时间进程 重建和体内发展的时间过程 T细胞免疫能力定义为对以下物质的反应能力： 一种与输入的T细胞数量相关的器官移植物 在骨髓中，与骨髓细胞剂量或 造血重建的时间，提高了 输注的T细胞耗尽的骨髓中的残余T细胞发挥了 在随后的T细胞群的产生中起中心作用。 这意味着移植的骨髓中T细胞的产生 灵长类动物可能与小鼠不同。

Concerns that a functionally effective T cell repertoire might never develop in the setting of MHC-micmatched marrow transplantation are based on the defective T cell responses in vivo observed in murine bone marrow chimeras constructed between MHC disparate strains. The incompetence is not due to inherent T cell defects, but rather to the restriction specificities of the T cells such that those MHC determinants recognized as self (host type) are not expressed by the antigen presenting cells which are of donor type. The T cell response to antigen is therefore defective. To evaluate whether T cell maturation is comparable in mouse and man, the development of T cell responses in a primate, the rhesus monkey, has been studied. The biology of T cell recovery has first been investigated in animals following T cell depleted autologous marrow transplantation. The time course of CD4+ T cell reconstitution and the time course of the development of in vivo T cell immuno-competence as defined by the ability to respond to an organ allograft correlated with the number of T cells infused in the marrow, and did not correlate with marrow cell dose or with time of hematopoietic reconstitution, raising the possibility that residual T cells in the infused T cell depleted marrow played a central role in the generation of susequent T cell populations. This would imply that the generation of T cells in marrow grafted primates may not be the same as in the mouse.