PERIODONTAL DISEASE RESEARCH CENTER

该中心的主要目标是开发用于 牙周病的诊断、治疗和预防。一个 一系列相关的临床、微生物学和免疫学 研究的目的就是为了实现这些目标。这个 临床组件旨在检测早期疾病活动 利用高度灵敏的检测方法，如电子 恒力探头，已被证明是高度敏感的 而且是可复制的。微生物学和免疫学研究 旨在调查难治性和非霍奇金淋巴瘤的微生物病因 化脓性牙周病和定义 特定微生物与寄主之间的相互关系 免疫反应。将进行临床测量以 验证各个站点是否处于积极进行的状态 治疗前的疾病和治疗后的缓解状态。 微生物群的组成和免疫反应将 对每个患者进行纵向检查，以确定 不同治疗方案的总体效果。测定法 不同牙周治疗方法对临床疗效的影响 宿主的微生物区系和免疫反应，应该 导致更合理的方法来处理这些问题 疾病。通过彻底调查 与牙周病相关的相关因素 过程中，希望为合理预防和治疗奠定基础 将会建立起来。 松鼠猴(Saimiri Scureus)研究的目的是 建立疑似猪瘟患者体内定植模型 牙周病原菌(牙周炎、牙周炎、牙周炎)。 伴生放线菌)，然后考察 关于殖民的免疫。具体目标是：(1) 在一种或多种牙龈下细菌之间建立联系 (2)定义了 对可疑牙周病原体的免疫力；(3)调查 猴的感染和口腔定植机制的研究 病原体；(4)鉴定和表征来自 通常感染和对抗的病原菌 免疫猴产生抗体；(5)检测免疫效果 小鼠龈下菌斑定植的免疫研究 病原菌。 从这些研究中，与疾病有关的微生物区系以及 将定义对这些细菌的体液免疫反应。一个 经鉴定的菌斑定植模型 病原体将被开发出来。然后，该模型将用于 研究体液免疫反应对机体免疫的调节作用 疑似病原体的口腔移居。关于这方面的信息 类型将为我们理解提供有价值的知识 并可能为牙周病的合理治疗提供依据 牙周病的免疫预防探讨。

The major objectives of this Center are to develop modalities for diagnosis, treatment, and prevention of periodontal diseases. A series of related clinical, microbiological, and immunological studies have been designed to address these objectives. The clinical component is designed to detect early disease activity utilizing highly sensitive detection methods such as an electronic constant-force probe which has been shown to be highly sensitive and reproducible. Microbiologic and immunologic studies are designed to investigate the microbial etiologies of refractory and suppurative periodontal diseases and to define the interrelationship between specific microorganisms and the host's immune response. Clinical measurements will be performed to verify that individual sites are in an actively progressing state of disease prior to therapy and in a state of remission after therapy. The composition of the microbiota and the immune response will be examined longitudinally in each patient to determine the overall effects of different therapeutic regimens. Determination of the effect of different periodontal therapies on the clinical response, the host's microbiota, and the immune response, should lead to more rational approaches in the treatment of these diseases. By thoroughly investigating the multiplicity of interrelated factors associated with the periodontal disease process, it is hoped that bases for rational prevention and therapy will be established. The objective of the squirrel monkey (Saimiri sciureus) study is to develop an in vivo model for colonization with suspected periodontal pathogens (e.g., B. gingivalis, H. actinomycetemcomitans) and then to examine the effects of immunization on colonization. The specific aims are: (1) establish an association between one or more subgingival bacteria (e.g., B. gingivalis) and disease; (2) define the relationship of immunity to suspected periodontal pathogens; (3) investigate the mechanisms of infection and oral colonization of monkeys with pathogens; (4) identify and characterize the antigens from pathogenic bacteria against which normally infected and immunized monkeys make antibody; and (5) test the effect of immunization on colonization of subgingival plaque with pathogenic bacteria. From the studies, the microbiota involved in disease as well as the humoral immune response to these bacteria will be defined. A model of colonization of subgingival plaque by identified pathogens will be developed. This model will then be used to study the potential of the humoral immune response to modulate the oral colonization by suspected pathogens. Information of this type will provide valuable knowledge to our understanding of periodontal diseases and possibly provide a basis for a rational approach to immunologic prevention of periodontal diseases.