PATHOGENESIS AND PREVENTION OF OSTEOPOROSIS

该计划项目赠款用于基础和临床研究， 骨质疏松症的发病机制和预防。 它包括一个核心 管理、临床服务和数据处理设施 和核心组织形态计量实验室 五大工程 其中将包括研究可能的 雌激素在骨中的作用机制及 拟南芥素、细胞因子和生长因子， 糖皮质激素对骨细胞功能影响及其机制探讨 骨质疏松症的遗传决定因素，以及临床 运动和雌激素预防乳腺癌的比较 绝经后骨质流失 第一年的试点项目将 研究骨量和形态的种族差异， 脊柱侧凸对骨量的影响以及用于治疗的方法 骨细胞的永生化 该项目将在 与骨领域正在进行的研究工作相结合 目前，在NIH的支持下， 上面列出的研究人员以及其他科学家在 康涅狄格大学健康中心。

This program project grant is for basic and clinical studies on the pathogenesis and prevention of osteoporosis. It includes a core facility for administration, clinical services, and data processing and a core histomorphometric laboratory. Five major projects will be undertaken which will include studies on the possible mechanism of action of estrogen in bone and the role of prostaglandins, cytokines, and growth factors, studies on the effect of glucocorticoids on bone cell function, and exploration of the genetic determinants of osteoporosis, and a clinical comparison of exercise and estrogen for the prevention of postmenopausal bone loss. Pilot projects in the first year will examine racial differences in bone mass and morphology, the effects of scoliosis on bone mass, and methods for the immortalization of bone cells. This program project will be integrated with ongoing research efforts in the area of bone metabolism currently carried out with NIH support by a number of the investigators listed above as well as other scientists at the University of Connecticut Health Center.