STRUCTURE AND FUNCTION OF MARKERS OF THE IMMUNE SYSTEM

这一计划项目是从一个长期的兴趣发展而来的 年纽约大学医学中心积极互动的调查小组 与免疫系统相关的细胞表面分子。参赛者 汇集了各种各样的兴趣和技术技能，范围广泛 从体细胞遗传学到经典的蛋白质化学，包括 分子遗传学，DNA介导的基因转移和血清学 常规抗体和单抗。该组织作为 在癌症中心的分子免疫科工作了5年，是 纽约大学规模更大的免疫学小组每周都会聚在一起 在过去的25年里。 该项目的重点是细胞表达的分化抗原 对免疫系统的影响。提出了五个方案：1)功能 补体受体2(CR2)；2)人补体受体2的分离和结构 巨噬细胞标记基因；3)微小H基因的克隆；4)作用的研究 T细胞分化抗原在效应器功能表达中的作用 在克隆的胸腺细胞系中；5)淋巴细胞异源二聚体 表达：染色体是反转的吗？膜组分特性 B细胞、T细胞和巨噬细胞正在研究中，特别是 人们正将注意力集中在控制其生命的机制上 表情。了解免疫的每一种成分的作用 系统，最终将需要识别和表征 由这些细胞产生的调节其特定功能的分子。 这些分子中的许多很可能在细胞表面表达， 它们与环境相互作用，服务于效应器或 识别功能。它们的表达受到高度调控，涉及到 发展的顺序和协调，因为几个产品 在这个过程的每一步，基因都是同时需要的。

This program project has developed from the long standing interest of an active and interactive group of investigators at the NYU Medical Center in cell surface molecules of relevance to the immune system. The participants bring together a wide variety of interests and technical skills, ranging from somatic cell genetics to classic protein chemistry and includes molecular genetics, DNA-mediated gene transfer and serology with conventional and monoclonal antibodies. The group has collaborated as the Molecular Immunology Unit of the Cancer Center for 5 years and is part of the larger immunology group at NYU which has met together on a weekly basis for the past 25 years. The project focuses on the differentiation antigens expressed by the cells of the immune system. Five projects are proposed: 1) The function of complement receptor 2 (CR2); 2) Isolation and structure of a human macrophage marker gene; 3) Cloning of minor H genes; 4) Studies of the role of T-cell differentiation antigens in the expression of effector functions in cloned prothymocyte cell lines; and 5) lymphocyte heterodimer expression: Do chromosomes converse? Membrane components characteristic of B-cells, T-cells and macrophages are under study and particular attention is being devoted to the mechanisms that control their expression. To understand the role of each of the components of the immune system, it will ultimately be necessary to identify and characterize the molecules produced by these cells which mediate their specific function. Many of these molecules are likely to be expressed at the cell surface, where they interact with the environment, serving either effector or recognition functions. Their expression is highly regulated in terms of developmental sequence and coordinated in that the products of several genes are required simultaneously at each step in the process.