MODELING OF TIME-DOSE RESPONSE OF HUMAN TUMORS AND NORMAL TISSUES

放射治疗的目的是控制肿瘤。 鉴于克隆原 在尽可能短的时间内提供必要的剂量是有意义的。 尽可能的时间，尽可能的有针对性。 限制因素 在肿瘤耐药是正常组织反应：正常组织反应必须 不超过“容忍度”。 高分子材料的开发与应用 技术，特别是在计算机和基于计算机的和辅助的 影像学在肿瘤定位和治疗方面取得了巨大进展 规划，甚至在交付技术和质量方面 保证，即，这个问题的空间方面。 关于下列事项的决策 剂量的量及其随时间的分布（通过分次或 然而，延长）仍然基本上是不规则的。 本 项目继续发展和探索一个理论 描述肿瘤以及正常组织的时间-剂量反应。 我们的工作集中在线性二次模型的扩展。 一 本文[1]致力于建立 α，β模型，包括修复亚致死性损伤的常规 和（加速）超分割和α，β模型 持续低剂量率。 高剂量率影响的研究 与低剂量率近距离放射治疗的比较正在进行中。 交互式 计算机程序和图形工具，以帮助临床指导， 寻找与恒定肿瘤控制相容的高剂量率 因为没有更严重的毒性达到有用的阶段。 改变 与医务人员变动有关的优先事项暂时 减缓了事态的发展。

The purpose of radiation therapy is tumor control. In view of clonogen proliferation it makes sense to deliver the necessary dose in as short a time as possible,and as well-targeted as possible. The limiting factor in tumor resistant is normal tissue reaction: Normal tissue reaction must not exceed "tolerance" level. The development and application of high technology particularly in computers and computer based and assisted imaging has stimulated great progress in tumor localization and treatment planning, and even in the technology of delivery and its quality assurance, i.e., the spatial aspects of the issue. Decision-making as to the amount of dose and its distribution over time (by fractionation or protraction) is still essentially empiricle, however. The present project continues the development and exploration of a theoretical description of time-dose response of tumors as well as normal tissues. Our work has concentrated on extensions of the Linear-Quadratic model. A paper [1] was devoted to establishing the relationship between the alpha,beta model, including repair of sublethal damage for conventional and (accelerated) hyperfractionation and the alpha,beta model for continuous low dose rate. The study of implications of high dose rate versus low dose rate brachytherapy therapy is ongoing. An interactive computer program and graphical tools to help clinical guidance in the search for high dose rates compatible with constant tumor control as well as no more severe toxicity has reached a useful stage. Changed priorities related to changes in the medical staff have temporarily slowed-down the developments.