NATURAL HISTORY OF ORAL MANIFESTATIONS OF HIV INFECTION

检测血清呈阳性的美国陆军人员和家属 为人类免疫缺陷病毒(HIV)提供医疗服务 沃尔特里德陆军医疗中心的检查和治疗。科目 也被邀请参加一项研究方案，以研究 《艾滋病毒感染的自然史》，由沃尔特里德军团主持 研究所。口腔健康研究部分，由 NIDR是这项自然历史研究的一部分。 口腔部分记录了口腔疾病的患病率和发病率 与HIV感染阶段有关的病理情况和 系统性疾病。与这些情况相关的风险因素有 也具有口腔表现的特点和作用，早在 研究疾病进展的预测因子或标记物。范围： 重点是粘膜病理学，牙周状况，念珠菌 感染和唾液成分。到目前为止，结果显示增长 在粘膜病理学中，随着HIV的进展，T4细胞计数减少 疾病。最常见的粘膜病变是口腔粘膜病变。 念珠菌病和毛状白斑。破坏性牙周病有 在接受检查的受试者中，约有25%的人发生了这种情况。纵向研究 显示大约30%的人在进入时没有粘膜病变 随访6个月后出现病理改变。

United States Army personnel and dependents who have tested seropositive for the Human Immunodeficiency Virus (HIV) are given medical examinations and treatment at Walter Reed Army Medical Center. Subjects are also invited to participate in a research protocol to study the natural history of HIV infection, conducted by the Walter Reed Army Institute of Research. An oral health research component conducted by NIDR is a part of this natural history study. The oral component documents the prevalence and incidence of oral pathologic conditions in relation to the stage of HIV infection and systemic disease. Risk factors associated with these conditions are also characterized, and the role of oral manifestations as early predictors or markers of disease progression are studied. Areas of emphasis are mucosal pathologies, periodontal conditions, candidal infections, and salivary constituents. Results to date show an increase in mucosal pathology as T4 cell counts decrease with progression of HIV disease. The most commonly observed mucosal pathologies were oral candidiasis and hairy leukoplakia. Destructive periodontal disease has occurred in about 25 percent of subjects examined. Longitudinal studies showed that about 30% of persons free from mucosal pathology at entry presented with pathology after six months of follow-up.